Bradykinin, Kallidin and Kallikrein

Supplement

  • Ervin G. Erdös

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 25 / 1)

Table of contents

  1. Front Matter
    Pages I-XXII
  2. F. Fiedler
    Pages 103-161
  3. R. Vogel
    Pages 163-225
  4. J. J. Pisano
    Pages 273-285
  5. C. E. Odya, T. L. Goodfriend
    Pages 287-300
  6. R. C. Talamo, T. L. Goodfriend
    Pages 301-309
  7. A. R. Johnson
    Pages 357-399
  8. N. A. Terragno, A. Terragno
    Pages 401-426
  9. E. G. Erdös
    Pages 427-487
  10. K. Bhoola, M. Lemon, R. Matthews
    Pages 489-523
  11. P. E. Ward, H. S. Margolius
    Pages 525-548
  12. R. W. Colman, P. Y. Wong
    Pages 569-607
  13. T. S. Paskhina, A. P. Levitsky
    Pages 609-656
  14. Back Matter
    Pages 657-820

About this book

Introduction

Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish­ ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter­ actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.

Keywords

Bradykinin Histamin Kallidin Kallikrein Prostaglandin blood central nervous system chemistry circulation hypertension nervous system peptides pharmacology protein regulation

Editors and affiliations

  • Ervin G. Erdös
    • 1
  1. 1.Departments of Pharmacology, and Internal MedicineThe University of Texas, Southwestern Medical SchoolDallasUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-67301-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-67303-0
  • Online ISBN 978-3-642-67301-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
Industry Sectors
Biotechnology
Pharma