Snake Venoms

  • Chen-Yuan Lee

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 52)

Table of contents

  1. Front Matter
    Pages I-XXXIII
  2. History, Ecological and Zoological Aspects

  3. Chemistry and Biochemistry of Snake Venoms

    1. Front Matter
      Pages 59-59
    2. S. Iwanaga, T. Suzuki
      Pages 61-158
    3. D. J. Strydom
      Pages 258-275
    4. R. A. Hogue-Angeletti, R. A. Bradshaw
      Pages 276-294
  4. Pharmacology of Snake Venoms

    1. Front Matter
      Pages 307-307
    2. E. X. Albuquerque, A. T. Eldefrawi, M. E. Eldefrawi
      Pages 377-402
    3. E. Condrea
      Pages 448-479
    4. C. Y. Lee, S. Y. Lee
      Pages 547-590
    5. A. M. Rothschild, Z. Rothschild
      Pages 591-628

About this book

Introduction

The past decade has been a period of explosion of knowledge on the chemistry and pharmacology of snake toxins. Thanks to the development of protein chemistry, nearly a hundred snake toxins have been purified and sequenced, representing one of the largest families of sequenced proteins. Moreover, the mode of action of these toxins has been largely elucidated by the concerted efforts of pharmacologists, electro physiologists, and biochemists. As a result of these studies, some of the snake toxins, e.g., a-bungarotoxin and cobra neurotoxins, have been extensively used as specific markers in the study of the acetylcholine receptors. Indeed, without the discovery of these snake toxins, our knowledge of the structure and function of nicotinic acetylcholine receptors would not have advanced so rapidly. The contribution of snake venom research to the biomedical sciences is not limited to the study of cholinergic receptors. Being one of the most concentrated enzyme sources in nature, snake venoms are also valuable tools in biochemical research. Venom phosphodiesterase, for example, has been widely used for structural studies of nucleic acids; proteinase, for the sequence studies of proteins and pep tides ; phospholipase A , for lipid research; and L-amino acid oxidase for identifying optical z isomers of amino acids. Furthermore, snake venoms have proven to be useful agents for clarifying some basic concepts on blood coagulation and some venom enzymes, e.g., thrombin-like enzymes and pro coagulants have been used as therapeutic agents.

Keywords

Acetylcholin Nicotin biochemistry care chemistry epidemiology hospital inflammation lipide nervous system nomenclature pharmacokinetics pharmacology physiology research

Editors and affiliations

  • Chen-Yuan Lee
    • 1
  1. 1.College of MedicineNational Taiwan UniversityTaipeiTaiwan, Republic of China

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66913-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66915-6
  • Online ISBN 978-3-642-66913-2
  • Series Print ISSN 0171-2004
  • About this book
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