Platelets and Their Factors

  • Franz von Bruchhausen
  • Ulrich Walter

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 126)

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. Platelet Development, Morphology and Physiology

    1. Front Matter
      Pages 1-1
    2. A. S. Brown, J. D. Erusalimsky, J. F. Martin
      Pages 3-26
    3. E. Morgenstern
      Pages 27-60
    4. G. H. van Zanten, P. G. de Groot, J. J. Sixma
      Pages 61-81
    5. A. Ruf, M. M. Frojmovic, H. Patscheke
      Pages 83-98
  3. Platelet Biochemistry, Signal Transduction

    1. Front Matter
      Pages 99-99
    2. C. Gachet, J.-P. Cazenave
      Pages 117-134
    3. F. Ushikubi, M. Hirata, S. Narumiya
      Pages 135-154
    4. K. J. Clemetson, J. Polgár
      Pages 155-179
    5. D. Koesling, B. Nürnberg
      Pages 181-218
    6. E. Butt, U. Walter
      Pages 219-230
    7. S. Nakashima, Y. Banno, Y. Nozawa
      Pages 231-246
    8. P. Presek, E. A. Martinson
      Pages 263-296
    9. S. P. Watson
      Pages 297-323
    10. K. S. Authi
      Pages 325-370

About this book

Introduction

Platelets playa fundamental, life-saving role in hemostasis and blood clotting at sites of vascular injury. Unwanted platelet activation and arterial thombus formation are, however, implicated in the onset of myocardial infarction, stroke, and other cardiovascular diseases. Acceptance that platelets play a major role in the pathogenesis of atherosclerosis including coronary heart disease has revolutionized the pharmacological treatment of cardiovascular diseases, and aspirin is now an essential antiplatelet drug and the golden standard for future developments. Yet the search for better and perhaps safer antiplatelet drugs is one of the most active areas of investigation in both basic and clinical research. Platelets, especially human platelets, have also emerged as one of the major models for the study of inter- and intracellular signal transduction pathways. Many biochemists, cell biologists, pharmacologists, pathologists, hematologists, and cardiologists find platelets useful for studying processes such as adhesion, inside-out and outside-in signalling through the plasma membrane, channels, calcium homeostasis, protein kinases, the network of intracellular signal transduction cascades, and the release of vasoactive substances. The aim of the editors has been to compile chapters summarizing the current state-of-the-art information on the biochemistry, cell biology, pharmacology, and physiologic and pathophysiologic roles of human platelets. We hope that this volume represents the major aspects of current platelet research although it is perhaps inevitable that certain areas are covered less thoroughly than others. We would like to acknowledge the excellent help and support of the Springer-Verlag staff, in particular that of Ms. Doris Walker.

Keywords

Calcium Nucleotide Purine biochemistry biomolecule cardiovascular disease enzymes metabolism pathophysiology pharmacology physiology proteins receptor research translation

Editors and affiliations

  • Franz von Bruchhausen
    • 1
  • Ulrich Walter
    • 2
  1. 1.Institut für PharmakologieFreie Universität BerlinBerlinGermany
  2. 2.Institut für Klinische Biochemie und PathobiochemieMedinzinische UniversitätsklinikWürzburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60639-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64488-7
  • Online ISBN 978-3-642-60639-7
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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