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Stereochemical Aspects of Drug Action and Disposition

  • Book
  • © 2003

Overview

Editors:
  1. Michel Eichelbaum

    1. Institut für Klinische Pharmakologie, Dr. Margarete-Fischer-Bosch, Stuttgart, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Bernard Testa

    1. School of Pharmacy, University of Lausanne School of Pharmacy, Lausanne, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  3. Andrew Somogyi

    1. Dept. of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 153)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XXV
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  3. Experimental Pharmacology

    1. Front Matter

      Pages 141-141
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    2. Chiral Recognition in Biochemical Pharmacology: An Overview

      • B. Testa, J. M. Mayer
      Pages 143-159

    3. Enantioselectivity in Drug-Receptor Interactions

      • W. Soudijn, I. Van Wijngaarden, A. P. Ijzerman
      Pages 161-182

    4. Mechanisms of Stereoselective Binding to Functional Proteins

      • G. Klebe
      Pages 183-198

    5. Stereoselective Drug-Channel Interactions

      • C. Valenzuela
      Pages 199-228

    6. Stereoselective Bioactivation and Bioinactivation — Toxicological Aspects

      • N. P. E. Vermeulen
      Pages 229-248

  4. Drug Absorption, Distribution, Metabolism, Elimination

    1. Front Matter

      Pages 249-249
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    2. Intestinal Drug Transport: Stereochemical Aspects

      • H. Spahn-Langguth, C. Dressler, C. Leisen
      Pages 251-288

    3. Enantioselective Plasma and Tissue Binding

      • P. J. Hayball, D. Mauleón
      Pages 289-311

    4. Stereoselective Drug Metabolism and Drug Interactions

      • A. S. Gross, A. Somogyi, M. Eichelbaum
      Pages 313-339

    5. Metabolic Chiral Inversion of 2-Arylpropionic Acids

      • I. Tegeder, K. Williams, G. Geisslinger
      Pages 341-354

    6. Stereoselective Renal Elimination

      • C. M. Brett, R. J. Ott, K. M. Giacomini
      Pages 355-375

  5. Implications for Drug Development and Therapy

    1. Front Matter

      Pages 377-377
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Keywords

Editors and Affiliations

  • Institut für Klinische Pharmakologie, Dr. Margarete-Fischer-Bosch, Stuttgart, Germany

    Michel Eichelbaum

  • School of Pharmacy, University of Lausanne School of Pharmacy, Lausanne, Switzerland

    Bernard Testa

  • Dept. of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia

    Andrew Somogyi

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