Overview
- Introduces the reader to gas phase nucleic acid investigations: from the transfer to the gas phase, over spectroscopy to fragmentation reactions
- Highly interdisciplinary work: relevant to biophysicists, physical and organic chemists, and even pharmacologists
- Describes current and prospective research and applications of nucleic acids in the gas phase
- Summarizes research results using a multitude of different physical chemical techniques: from spectroscopy, over mass spectrometry to coupled techniques
Part of the book series: Physical Chemistry in Action (PCIA)
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Table of contents (10 chapters)
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Front Matter
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Methods
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Front Matter
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Applications
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Front Matter
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Back Matter
Keywords
About this book
This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation.
The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.
Reviews
“‘Nucleic Acids in the Gas Phase,’ edited by Valerie Gabelica, takes on the task of telling the story of how mass spectrometry can reveal important information about these biomolecules, even in a small data format. … the volume succeeds in its overall goal to expose the reader to the breadth of information that can be gleaned from nucleic acids using mass spectrometry … . this information advances our understanding and appreciation of nucleic acid structure and function.” (Patrick A. Limbach, Journal of The American Society for Mass Spectrometry, Vol. 26, 2015)
Editors and Affiliations
Bibliographic Information
Book Title: Nucleic Acids in the Gas Phase
Editors: Valérie Gabelica
Series Title: Physical Chemistry in Action
DOI: https://doi.org/10.1007/978-3-642-54842-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-54841-3Published: 11 August 2014
Softcover ISBN: 978-3-662-51126-8Published: 22 September 2016
eBook ISBN: 978-3-642-54842-0Published: 28 July 2014
Series ISSN: 2197-4349
Series E-ISSN: 2197-4357
Edition Number: 1
Number of Pages: XII, 287
Number of Illustrations: 72 b/w illustrations, 70 illustrations in colour
Topics: Mass Spectrometry, Nucleic Acid Chemistry, Biological and Medical Physics, Biophysics, Spectroscopy/Spectrometry, Bioorganic Chemistry, Physical Chemistry
Industry Sectors: Biotechnology, Chemical Manufacturing