Development of Innovative Drugs via Modeling with MATLAB

A Practical Guide

  • Ronald Gieschke
  • Daniel Serafin

Table of contents

  1. Front Matter
    Pages i-xv
  2. Ronald Gieschke, Daniel Serafin
    Pages 1-20
  3. Ronald Gieschke, Daniel Serafin
    Pages 21-38
  4. Ronald Gieschke, Daniel Serafin
    Pages 39-85
  5. Ronald Gieschke, Daniel Serafin
    Pages 87-141
  6. Ronald Gieschke, Daniel Serafin
    Pages 143-205
  7. Ronald Gieschke, Daniel Serafin
    Pages 207-238
  8. Ronald Gieschke, Daniel Serafin
    Pages 239-271
  9. Ronald Gieschke, Daniel Serafin
    Pages 273-303
  10. Ronald Gieschke, Daniel Serafin
    Pages 305-313
  11. Back Matter
    Pages 315-399

About this book


The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens?

Written from the industry perspective and based on many years of experience, this book offers:

§  Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs

§  Guidance for exploration and modification of these programs to enhance the understanding of key principles

§  Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature

§  A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling.

Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.


Clinical trial simulation Drug discovery Pharmacodynamics Pharmacometrics

Authors and affiliations

  • Ronald Gieschke
    • 1
  • Daniel Serafin
    • 2
  1. 1.Pharma Research and Early Development (p Translational Research Sciences (TRS)F. Hoffmann-La Roche LtdBaselSwitzerland
  2. 2.F. Hoffmann-La Roche LtdBaselSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-39764-6
  • Online ISBN 978-3-642-39765-3
  • About this book
Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods