Proteopathic Seeds and Neurodegenerative Diseases

  • Mathias Jucker
  • Yves Christen

Part of the Research and Perspectives in Alzheimer's Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Jason Greenwald, Roland Riek
    Pages 33-46
  3. Per Westermark, Gunilla T. Westermark
    Pages 47-60
  4. Sarah K. Fritschi, Bahareh Eftekharzadeh, Giusi Manfredi, Tsuyoshi Hamaguchi, Götz Heilbronner, Amudha Nagarathinam et al.
    Pages 61-69
  5. C. Duran-Aniotz, R. Morales, I. Moreno-Gonzalez, C. Soto
    Pages 71-86
  6. Florence Clavaguera, Markus Tolnay, Michel Goedert
    Pages 87-95
  7. Nolwen L. Rey, Elodie Angot, Christopher Dunning, Jennifer A. Steiner, Patrik Brundin
    Pages 97-113
  8. Eric R. Kandel, Irina Derkatch, Elias Pavlopoulos
    Pages 131-152
  9. Back Matter
    Pages 153-155

About this book

Introduction

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans, and appears to occur many years before the onset of clinical symptoms. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, has increasingly implicated corruptive protein templating, or seeding, as a prime factor in the neurodegenerative process. The prion-like corruption of proteins also characterizes such clinically and etiologically diverse neurological disorders as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of affected proteins thus could reveal universal principles and common therapeutic targets for some of the most devastating and intractable human brain disorders.

Keywords

Parkinson's disease amyloidosis prions synucleinopathies

Editors and affiliations

  • Mathias Jucker
    • 1
  • Yves Christen
    • 2
  1. 1., Dept. Cellular NeurologyUniversity of TübingenTübingenGermany
  2. 2.Fondation IPSENBoulogne-Billancourt CedexFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-35491-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-35490-8
  • Online ISBN 978-3-642-35491-5
  • Series Print ISSN 0945-6066
  • Series Online ISSN 2196-310X
  • About this book
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