Metallocorroles for Attenuation of Atherosclerosis

  • Adi┬áHaber

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Adi Haber
    Pages 1-14
  3. Adi Haber
    Pages 15-15
  4. Adi Haber
    Pages 17-44
  5. Adi Haber
    Pages 45-66
  6. Adi Haber
    Pages 67-69
  7. Adi Haber
    Pages 71-86
  8. Back Matter
    Pages 87-87

About this book

Introduction

Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

Keywords

Amphipolar Corroles Cardiovascular Disease Catalytic Antioxidants Cholesterol Biosynthesis High Density Lipoproteins Low Density Lipoproteins Schulich Faculty of Chemistry Technion Transition-metal Corrole Complexes

Authors and affiliations

  • Adi┬áHaber
    • 1
  1. 1., Schulich Faculty of ChemistryTechnion Israel Institute of TechnologyHaifaIsrael

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-30328-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-642-30327-2
  • Online ISBN 978-3-642-30328-9
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book
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