© 2012

RNA Metabolism in Trypanosomes

  • Albrecht Bindereif

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 28)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Nancy R. Sturm, Jesse R. Zamudio, David A. Campbell
    Pages 29-47
  3. Christian Preußer, Nicolas Jaé, Arthur Günzl, Albrecht Bindereif
    Pages 49-77
  4. Christine Clayton
    Pages 79-97
  5. Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, Juan D. Alfonzo
    Pages 99-121
  6. Shulamit Michaeli
    Pages 123-148
  7. Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, Christian Tschudi
    Pages 167-185
  8. Michal Shapira, Alexandra Zinoviev
    Pages 187-214
  9. Dmitri A. Maslov, Rajendra K. Agrawal
    Pages 215-236
  10. Jan Mani, Kapila Gunasekera, Isabel Roditi
    Pages 237-265
  11. Back Matter
    Pages 267-271

About this book


Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating features, many of which have helped to establish new paradigms in other biological systems. This applies in particular to studies in gene expression and regulation, which benefit enormously from the trypanosome genome projects and from the new genome-wide approaches recently introduced in trypanosome research. This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses. Recent progress in RNA-focused research in trypanosomatids promises to yield novel insights into trypanosome-specific features, as well as to reveal in the process new potential therapeutic strategies for combating these parasitic diseases.


Gene Expression Molecular Biology RNA RNA Metabolism RNA Polymerase Trypanosomes

Editors and affiliations

  • Albrecht Bindereif
    • 1
  1. 1., Department of Biology and ChemistryJustus Liebig University of GiessenGiessenGermany

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