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Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

  • Book
  • © 2012

Overview

Editors:
  1. Michail Ignatiadis

    1. , Breast Cancer Translational Res. Lab., Institut Jules Bordet, Brussels, Belgium

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  2. Christos Sotiriou

    1. , Breast Cancer Translational Res. Lab., Institut Jules Bordet, Brussels, Belgium

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  3. Klaus Pantel

    1. Zentrum für Experimentelle Medizin, Inst. Tumorbiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

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  • Provides up-to-date information on topical issues concerning minimal residual disease in breast cancer patients
  • Appraises the technologies available for detection and characterization of circulating and disseminated tumor cells (CTCs/DTCs)
  • Discusses the relevance of CTCs and DTCs in breast cancer clinical research and practice, and the role of other blood-based biomarkers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 195)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer: Open Questions for Research

      • Michail Ignatiadis, Christos Sotiriou, Klaus Pantel
      Pages 3-9

  3. Minimal Residual Disease and Breast Cancer Metastasis

    1. Front Matter

      Pages 11-11
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  4. Minimal residual disease and breast cancer metastasis

    1. Self-Seeding in Cancer

      • Elizabeth Comen, Larry Norton
      Pages 13-23

    2. Microenvironments Dictating Tumor Cell Dormancy

      • Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis, Julio A. Aguirre-Ghiso
      Pages 25-39

  5. Technologies for Circulating Tumor Cell and Disseminated Tumor Cell Detection and Characterization

    1. Front Matter

      Pages 41-41
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  6. Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization

    1. Immunomagnetic Separation Technologies

      • Astrid E. L. M. Hoeppener, Joost F. Swennenhuis, Leon W. M. M. Terstappen
      Pages 43-58

    2. Microfluidic Technologies

      • Ali Asgar. S. Bhagat, Chwee Teck Lim
      Pages 59-67

    3. EPISPOT Assay: Detection of Viable DTCs/CTCs in Solid Tumor Patients

      • Catherine Alix-Panabières
      Pages 69-76

    4. Advances in Optical Technologies for Rare Cell Detection and Characterization

      • Lou Dietz, Richard Bruce
      Pages 77-85

    5. Size-Based Enrichment Technologies for CTC Detection and Characterization

      • Anthony Williams, Marija Balic, Ram Datar, Richard Cote
      Pages 87-95

    6. Emerging Technologies for CTC Detection Based on Depletion of Normal Cells

      • Maryam Lustberg, Kris R. Jatana, Maciej Zborowski, Jeffrey J. Chalmers
      Pages 97-110

    7. Molecular Assays for the Detection and Characterization of CTCs

      • Evi S. Lianidou, Athina Markou
      Pages 111-123

    8. Multiplex Molecular Analysis of CTCs

      • Anieta M. Sieuwerts, Stefanie S. Jeffrey
      Pages 125-140

  7. Other Blood-Based Biomarkers

    1. Front Matter

      Pages 141-141
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  8. Other blood-based biomarkers

    1. Circulating DNA and Next-Generation Sequencing

      • Susanna Cooke, Peter Campbell
      Pages 143-149

    2. Circulating MicroRNAs as Noninvasive Biomarkers in Breast Cancer

      • Maria Angelica Cortez, James William Welsh, George Adrian Calin
      Pages 151-161

    3. Circulating Endothelial Cells and Circulating Endothelial Progenitors

      • Patrizia Mancuso, Angelica Calleri, Francesco Bertolini
      Pages 163-170

  9. Disseminated Tumor Cells and Circulating Tumor Cells in Breast Cancer Clinical Research and Practice

    1. Front Matter

      Pages 171-171
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Keywords

About this book

This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.

Editors and Affiliations

  • , Breast Cancer Translational Res. Lab., Institut Jules Bordet, Brussels, Belgium

    Michail Ignatiadis, Christos Sotiriou

  • Zentrum für Experimentelle Medizin, Inst. Tumorbiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

    Klaus Pantel

Bibliographic Information

  • Book Title: Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer

  • Editors: Michail Ignatiadis, Christos Sotiriou, Klaus Pantel

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-28160-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2012

  • Hardcover ISBN: 978-3-642-28159-4Published: 23 April 2012

  • Softcover ISBN: 978-3-642-44587-3Published: 09 May 2014

  • eBook ISBN: 978-3-642-28160-0Published: 23 April 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XIV, 254

  • Topics: Oncology, Gynecology, Surgical Oncology, Pathology, Cancer Research

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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