Overview
- Comprehensive overview on the molecular basis of fragile X syndrome
- First book to cover all models used to investigate fragile X syndrome
- Includes state-of-of the art approaches like epigenetics
- Includes supplementary material: sn.pub/extras
Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 54)
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About this book
Introduction.-Probing Astrocyte Function in Fragile X Syndrome.- Neural Stem Cells.- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.– The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome.- Behavior in a Drosophila model of Fragile X.- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome.- Fragile X Mental Retardation Protein and Stem Cells.- Manipulating the Fragile X Mental Retardation Proteins in the Frog.- Exploring the Zebra finch Taeniopygia gutta as a Novel Animal Model for the Speech-language Deficit of Fragile X Syndrome.- Neuroendocrine Alterations in the Fragile X Mouse.- Taking STEPs forward to understanding Fragile X Syndrome.- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease.- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome.- Clinical Aspects of the Fragile X Syndrome.- Fragile X Syndrome: A Psychiatric Perspective.- Fragile X Syndrome and Targeted Treatment Trials.- The Fragile X-associate Tremor Ataxia Syndrome.- Vignettes: Models in Absentia.
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Keywords
Table of contents (19 chapters)
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Missing Models
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Modeling Fragile X Syndrome
Editors: Robert B. Denman
Series Title: Results and Problems in Cell Differentiation
DOI: https://doi.org/10.1007/978-3-642-21649-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2012
Hardcover ISBN: 978-3-642-21648-0Published: 20 October 2011
Softcover ISBN: 978-3-642-27010-9Published: 29 November 2013
eBook ISBN: 978-3-642-21649-7Published: 08 July 2014
Series ISSN: 0080-1844
Series E-ISSN: 1861-0412
Edition Number: 1
Number of Pages: XII, 392
Topics: Cell Biology, Human Genetics, Molecular Medicine, Neurobiology, Stem Cells, Gene Therapy
Industry Sectors: Biotechnology, Pharma