Behavioral Neurobiology of Schizophrenia and Its Treatment

  • Neal R. Swerdlow

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 4)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Elizabeth Bromley, John S. Brekke
    Pages 3-21
  3. Tejal Kaur, Kristin S. Cadenhead
    Pages 97-121
  4. Dennis H. Kim, Stephen M. Stahl
    Pages 123-139
  5. Cara R. Rabin, Steven J. Siegel
    Pages 141-177
  6. Gregory G. Brown, Wesley K. Thompson
    Pages 181-214
  7. Nina Urban, Anissa Abi-Dargham
    Pages 215-242
  8. James J. Levitt, Laurel Bobrow, Diandra Lucia, Padmapriya Srinivasan
    Pages 243-281
  9. Deborah L. Levy, Anne B. Sereno, Diane C. Gooding, Gilllian A. O’Driscoll
    Pages 311-347
  10. Solomon Kalkstein, Irene Hurford, Ruben C. Gur
    Pages 373-390
  11. Jared W. Young, Xianjin Zhou, Mark A. Geyer
    Pages 391-433
  12. David W. Volk, David A. Lewis
    Pages 485-508
  13. Will J. Cronenwett, John Csernansky
    Pages 509-528
  14. Stephan Heckers, Christine Konradi
    Pages 529-553

About this book

Introduction

Schizophrenia research is in a dynamic state; this text gives a foothold for where we stand today, and a map for where our field may move tomorrow. Chapters on treatment describe major changes in clinical and neural targets, and new technologies for drug delivery, even as we struggle to address adverse effects of old treatments. The text next reviews advances in the experimental analysis of the schizophrenias. Where we once faced a paucity of biological signals, our field now sees an expanding list of clear neural abnormalities, and chapters focus on those in circuitry connecting prefrontal cortex, thalamus and mesial temporal lobes. The rapid evolution of schizophrenia genetics is described: older strategies for finding disorder genes, jettisoned in favor of studies of aberrant copy number variants, rare mutations or DNA methylation, and of molecular signaling pathways that trigger downstream disturbances in critical brain circuits. With what we now know about the complex biology of the schizophrenias, a key question becomes whether we can manipulate this biology in a way that fundamentally changes the course of this disorder. This text provides a context for students, investigators and clinicians to understand this stage in our evolving field, and to look ahead to the future of schizophrenia research.

Keywords

Neurobiology animal models genetics neural circuitry neuroimaging pathophysiology physiology psychiatric genetics schizophrenia

Editors and affiliations

  • Neal R. Swerdlow
    • 1
  1. 1., Dept. of Psychiatry - MC 0804University of San DiegoLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-13717-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-13716-7
  • Online ISBN 978-3-642-13717-4
  • Series Print ISSN 1866-3370
  • Series Online ISSN 1866-3389
  • About this book
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