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Adenosine Receptors in Health and Disease

  • Constance N. Wilson
  • S. Jamal Mustafa

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 193)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. William F. Kiesman, Elfatih Elzein, Jeff Zablocki
    Pages 25-58
  3. Gloria Cristalli, Christa E. Müller, Rosaria Volpini
    Pages 59-98
  4. Rao V. Kalla, Jeff Zablocki, Mojgan Aghazadeh Tabrizi, Pier Giovanni Baraldi
    Pages 99-122
  5. Kenneth A. Jacobson, Athena M. Klutz, Dilip K. Tosh, Andrei A. Ivanov, Delia Preti, Pier Giovanni Baraldi
    Pages 123-159
  6. S. Jamal Mustafa, R. Ray Morrison, Bunyen Teng, Amir Pelleg
    Pages 161-188
  7. John P. Headrick, Robert D. Lasley
    Pages 189-214
  8. Michael R. Blackburn, Constance O. Vance, Eva Morschl, Constance N. Wilson
    Pages 215-269
  9. Arvinder K. Dhalla, Jeffrey W. Chisholm, Gerald M. Reaven, Luiz Belardinelli
    Pages 271-295
  10. P.A. Borea, S. Gessi, S. Bar-Yehuda, P. Fishman
    Pages 297-327
  11. Constance N. Wilson, Ahmed Nadeem, Domenico Spina, Rachel Brown, Clive P. Page, S. Jamal Mustafa
    Pages 329-362
  12. Gulnur Com, J.P. Clancy
    Pages 363-381
  13. Igor Feoktistov, Italo Biaggioni, Bruce N. Cronstein
    Pages 383-397
  14. P. Fishman, S. Bar-Yehuda, M. Synowitz, J.D. Powell, K.N. Klotz, S. Gessi et al.
    Pages 399-441
  15. Volker Vallon, Hartmut Osswald
    Pages 443-470
  16. Ana M. Sebastião, Joaquim A. Ribeiro
    Pages 471-534
  17. Trevor W. Stone, Stefania Ceruti, Mariapia P. Abbracchio
    Pages 535-587
  18. Micaela Morelli, Anna R. Carta, Peter Jenner
    Pages 589-615
  19. Andreas Bauer, Kiichi Ishiwata
    Pages 617-642
  20. Back Matter
    Pages 643-652

About this book

Introduction

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Keywords

Adenosine Receptors Allergy and Asthma Asthma Autoimmune Disease Drug targets Inflammation Sepsis physiology

Editors and affiliations

  • Constance N. Wilson
    • 1
  • S. Jamal Mustafa
    • 2
  1. 1.Endacea, Inc.,Research Triangle ParkU.S.A.
  2. 2.Health Sciences CenterWest Virginia UniversityMorgantownU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-89615-9
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-89614-2
  • Online ISBN 978-3-540-89615-9
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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