Editors:
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 314)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological functions. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.
Editors and Affiliations
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Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
D. Branch Moody
Bibliographic Information
Book Title: T Cell Activation by CD1 and Lipid Antigens
Editors: D. Branch Moody
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-540-69511-0
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2007
Hardcover ISBN: 978-3-540-69510-3Published: 14 May 2007
Softcover ISBN: 978-3-642-08906-0Published: 30 November 2010
eBook ISBN: 978-3-540-69511-0Published: 10 May 2007
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 348
Topics: Immunology
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma