Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 178)
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Table of contents (21 chapters)
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Front Matter
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Tools for Conditional Mutagenesis
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Front Matter
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Examples of Conditional Disease Models
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Front Matter
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Keywords
About this book
Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Reviews
From the reviews:
"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. … The authors target general scientific researchers … . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. … an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody’s Review Service, July, 2008)
Editors and Affiliations
Bibliographic Information
Book Title: Conditional Mutagenesis: An Approach to Disease Models
Editors: Robert Feil, Daniel Metzger
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-540-35109-2
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2007
Hardcover ISBN: 978-3-540-35108-5Published: 28 November 2006
Softcover ISBN: 978-3-642-07121-8Published: 19 November 2010
eBook ISBN: 978-3-540-35109-2Published: 01 February 2007
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XII, 532
Topics: Pharmacology/Toxicology, Molecular Medicine, Human Genetics, Medical Biochemistry
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Health & Hospitals, Pharma