Targeted Interference with Signal Transduction Events

  • Bernd Groner

Part of the Resent Results in Cancer Research book series (RECENTCANCER, volume 172)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Constadina Arvanitis, Pavan K. Bendapudi, Pavan Bachireddy, Dean W. Felsher
    Pages 5-24
  3. Srinivasan Madhusudan, Trivadi S. Ganesan
    Pages 25-44
  4. Nancy E. Hynes
    Pages 45-57
  5. Klaus Podar, Noopur Raje, Kenneth C. Anderson
    Pages 77-97
  6. Kathryn Graham, Michael F. Olson
    Pages 125-153
  7. Judith S. Sebolt-Leopold, Roman Herrera, Jeffrey F. Ohren
    Pages 155-167

About this book

Introduction

Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.

Keywords

DNA antibody cancer cancer therapy cancer treatment development genome metastasis mutation protein receptor sequencing tumor tumor growth tumorigenesis

Editors and affiliations

  • Bernd Groner
    • 1
  1. 1.Georg-Speyer-HausInstitute for Biomedical ResearchFrankfurt am MainGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-31209-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-31208-6
  • Online ISBN 978-3-540-31209-3
  • Series Print ISSN 0080-0015
  • About this book
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