Humoral Primary Immunodeficiencies

  • Mario Milco D'Elios
  • Marta Rizzi

Part of the Rare Diseases of the Immune System book series (RDIS)

Table of contents

  1. Front Matter
    Pages i-x
  2. Laura Patrussi, Nagaja Capitani, Mario Milco D’Elios, Cosima T. Baldari
    Pages 1-20
  3. Arianna Troilo, Nagaja Capitani, Laura Patrussi, Cosima T. Baldari, Mario Milco D’Elios
    Pages 21-34
  4. Ulrich Salzer
    Pages 35-55
  5. Eduardo López-Granados
    Pages 57-66
  6. Vasssilios Lougaris, Alessandro Plebani
    Pages 67-76
  7. Ulrich Salzer
    Pages 77-82
  8. Menno C. van Zelm, Ismail Reisli
    Pages 83-95
  9. Jens Thiel
    Pages 97-99
  10. Astrid Bergbreiter, Ulrich Salzer
    Pages 101-112
  11. Laura Gámez-Díaz
    Pages 113-129
  12. Cristian R. Smulski, Patricia Odermatt, Hermann Eibel
    Pages 131-147
  13. Ulrich Salzer
    Pages 149-152
  14. Shancy P. Jacob, Julie E. Feusier, Karin Chen
    Pages 153-165
  15. Giuliana Roselli, Marinos Kallikourdis, Antonella Viola
    Pages 167-177
  16. Mirjam van der Burg, Andrew R. Gennery, Qiang Pan-Hammarström
    Pages 179-199
  17. K. Sofia Appelberg, Hassan Abolhassani, Lennart Hammarström
    Pages 201-215
  18. Isabella Quinti, Cinzia Milito, Rossella Carello, Federica Pulvirenti
    Pages 235-252
  19. Chiara Azzari, Clementina Canessa
    Pages 253-274
  20. Gianfranco Vitiello, Giacomo Emmi, Boaz Palterer
    Pages 275-289
  21. Lorenzo Lodi, Maurizio de Martino
    Pages 291-313
  22. Helen M. Chapel, Consuelo Anzilotti, Smita Y. Patel
    Pages 347-359
  23. Back Matter
    Pages 379-387

About this book


This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel humoral PID genes and related clinical applications, mucosal B cells, and the various clinical phenotypes of humoral PIDs. Aspects such as differential diagnosis, clinical management in children and adults, and the role of vaccines are also addressed. The authors are all recognized experts from Europe, Australia, and the United States. Humoral Primary Immunodeficiencies will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD and PhD students.


B-cell Antibodies Gammaglobulines Common Variable Immune Deficiency Clinical Phenotypes PID genes Autoimmunity Infections Lymphoma Cancer Tumor

Editors and affiliations

  • Mario Milco D'Elios
    • 1
  • Marta Rizzi
    • 2
  1. 1.Careggi HospitalDepartment of Clinical and Experimental Medicine, University of FlorenceFirenzeItaly
  2. 2.University Medical Centre Freiburg, Department of Rheumatology and Clinical Immunology and Center for Chronic ImmunodeficiencyFreiburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-91784-9
  • Online ISBN 978-3-319-91785-6
  • Series Print ISSN 2282-6505
  • Series Online ISSN 2283-6403
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology