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RNA Metabolism in Mitochondria

  • Jorge Cruz-Reyes
  • Michael W. Gray

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 34)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Srdja Drakulic, Jorge Cuellar, Rui Sousa
    Pages 1-15
  3. Christoph Freyer, Paula Clemente, Anna Wredenberg
    Pages 17-46
  4. Frédérique Weber-Lotfi, André Dietrich
    Pages 73-123
  5. Jorge Cruz-Reyes, Blaine H. M. Mooers, Vikas Kumar, Pawan K. Doharey, Joshua Meehan, Luenn Chaparro
    Pages 125-144
  6. Drahomíra Faktorová, Matus Valach, Binnypreet Kaur, Gertraud Burger, Julius Lukeš
    Pages 145-176
  7. Samantha Dodbele, Jane E. Jackman, Michael W. Gray
    Pages 177-198
  8. Jillian Houtz, Nicole Cremona, Jonatha M. Gott
    Pages 199-222
  9. Mizuki Takenaka, Anja Jörg, Matthias Burger, Sascha Haag
    Pages 223-249

About this book

Introduction

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5′ and 3′ ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.  

Keywords

Mitochondrial RNA Biology Translation and Transcription Editing and Splicing Processing and Maturation RNPs Structure and Evolution

Editors and affiliations

  • Jorge Cruz-Reyes
    • 1
  • Michael W. Gray
    • 2
  1. 1.Department of Biochemistry and BiophysicsTexas A&M UniversityCollege StationUSA
  2. 2.Department of Biochemistry and Molecular Biology, Centre for Comparative Genomics and Evolutionary BioinformaticsDalhousie UniversityHalifaxCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-78190-7
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-78189-1
  • Online ISBN 978-3-319-78190-7
  • Series Print ISSN 0933-1891
  • Series Online ISSN 1869-2486
  • Buy this book on publisher's site
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