Overview
- Unique resource that addresses the role of complement in malaria
- Written by experts from leading laboratories
- Important reference tool for malaria and complement researchers and immunologists alike
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.
Editors and Affiliations
About the editor
José A. Stoute, M.D.
Professor of Medicine, and Microbiology & Immunology
The Pennsylvania State University Hershey Medical Center and College of Medicine
Bibliographic Information
Book Title: Complement Activation in Malaria Immunity and Pathogenesis
Editors: José A. Stoute
DOI: https://doi.org/10.1007/978-3-319-77258-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-77257-8Published: 12 July 2018
Softcover ISBN: 978-3-030-08412-7Published: 21 December 2018
eBook ISBN: 978-3-319-77258-5Published: 03 July 2018
Edition Number: 1
Number of Pages: XII, 149
Number of Illustrations: 5 b/w illustrations, 17 illustrations in colour
Topics: Immunology, Parasitology, Infectious Diseases, Tropical Medicine, Laboratory Medicine
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma