New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules

  • Nicola Di Iorio

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas.

Organocatalysis is a relatively modern and “hot” topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently “recognized” the importance of these two areas and are focusing their efforts on studying them and the challenges they pose.

This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.

Keywords

Organocatalysis Vinylogous Reactivity Atropisomers Axial Chirality Desymmetrization Oxindoles Aminocatalysis Iminium Ion Catalysis Enamine Catalysis Friedel-crafts Reaction

Authors and affiliations

  • Nicola Di Iorio
    • 1
  1. 1.Department of Industrial Chemistry “Toso Montanari”University of BolognaBolognaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-74914-3
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-74913-6
  • Online ISBN 978-3-319-74914-3
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book
Industry Sectors
Chemical Manufacturing
Automotive
Biotechnology
Pharma