Anticoagulation Therapy

1. Front Matter

   Pages i-xxix

   PDF

2. Introduction

   • Joe F. Lau, Geoffrey D. Barnes, Michael B. Streiff

   Pages 1-6

3. Anticoagulants

   1. Front Matter

      Pages 7-7

      PDF

   2. Warfarin

      • Gregory C. Hadlock, Allison E. Burnett, Edith A. Nutescu

      Pages 9-30

   3. Unfractionated Heparin and Low-Molecular-Weight Heparin

      • Rhynn J. Malloy, Jessica Rimsans, Megan Rhoten, Katelyn Sylvester, John Fanikos

      Pages 31-57

   4. Parenteral Anticoagulants: Direct Thrombin Inhibitors and Pentasaccharides

      • Meghan L. Fletcher, Allison E. Burnett

      Pages 59-85

   5. Direct Oral Anticoagulants

      • Natalie S. Evans

      Pages 87-103

   6. Anticoagulation Reversal

      • Deborah Hornacek, Marcelo P. V. Gomes

      Pages 105-131

   7. Transitioning Between Anticoagulants

      • Maya Serhal, Marcelo P. V. Gomes

      Pages 133-150

4. Clinical Applications of Anticoagulant Therapy

   1. Front Matter

      Pages 151-151

      PDF

   2. The Anticoagulation Clinic

      • Nathan P. Clark, Daniel M. Witt

      Pages 153-173

   3. Perioperative Management of Anticoagulants

      • Ibrahim M. Ali, Alexander Volodarskiy, Joe F. Lau

      Pages 175-195

   4. Acute Coronary Syndromes

      • Nilay K. Patel, Sammy Elmariah

      Pages 197-216

   5. Antithrombotic Therapy for Patients with Atrial Fibrillation

      • Kyla M. Lara, Jonathan L. Halperin

      Pages 217-238

   6. Anticoagulant Strategies for Electrophysiology Procedures

      • Stuart J. Beldner, David L. Stern

      Pages 239-251

   7. Anticoagulation for Cardiac Prosthetic Devices: Prosthetic Heart Valves, Left Ventricular Assist Devices, and Septal Closure Devices

      • Matthew T. Crim, Supriya Shore, Suegene K. Lee, Bryan J. Wells

      Pages 253-295

   8. Anticoagulation in Venous Thromboembolism

      • Geoffrey D. Barnes, Elizabeth T. Renner

      Pages 297-323

   9. Thrombophilic States

      • Adriana Guigova, Tony Philip

      Pages 325-343

   10. Thrombophilia Testing

       • Teresa L. Carman

       Pages 345-357

   11. Heparin-Induced Thrombocytopenia

       • Emily Downs, Svetlana Goldman, Surabhi Palkimas, Aditya M. Sharma

       Pages 359-390

This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.

• anticoagulation therapy
• pharmacologic properties of anticoagulants
• clinical applications of anticoagulant therapy
• warfarin
• unfractionated heparin
• parenteral anticoagulants
• direct oral anticoagulants
• anticoagulation reversal
• thrombophilia
• venous thromboembolism therapy
• heparin-induced thrombocytopenia

• Associate Professor of Cardiology, Department of Cardiology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Manhasset, USA

  Joe F. Lau

• Assistant Professor, Division of Internal Medicine, Frankel Cardiovascular Center at the University of Michigan, Ann Arbor, USA

  Geoffrey D. Barnes

• Professor of Medicine and Pathology, Division of Hematology, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, USA

  Michael B. Streiff

Joe F. Lau MD, PhD, FACC, FASE, FSVM, RPVI


Associate Professor of Cardiology


Zucker School of Medicine at Hofstra/Northwell


Director of Vascular Medicine


Director of Non-Invasive Vascular Laboratory


Department of Cardiology


Northwell Health


New Hyde Park, NY




Geoffrey D. Barnes, MD, MSc


Assistant Professor


Frankel Cardiovascular Center at the University of Michigan


Department of Internal Medicine


Division of Cardiovascular Medicine


Ann Arbor, MI




Michael B. Streiff, MD


Associate Professor of Medicine and Pathology


Division of Hematology


Department of Medicine


The Johns Hopkins University School of Medicine


Baltimore, MD 

Policies and ethics