Overview
- The first book to combine current knowledge on gut and bone research
- Authored by international experts in the field
- Reviews exhaustively the key recent research regarding everything from signaling pathways to pathologies to intestinal environments
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1033)
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Table of contents (12 chapters)
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Front Matter
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Modulation of Gut Microbiota to Support Bone Health
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Front Matter
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Back Matter
Keywords
About this book
This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area. Â The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.
Editors and Affiliations
About the editors
Laura R. McCabe, PhD is the Director of the Molecular Metabolism and Disease Program at Michigan State University. Dr. McCabe’s research focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Her lab is taking an integrative approach to examine bone adaptation to diseases (such as diabetes and inflammatory bowel disease) and is working toward identifying mechanisms regulating bone formation by osteoblasts. Approaches include examination of transcription factor activity, intracellular signaling pathway activation, stem cell lineage selection, apoptosis, metabolism and immune system contributions utilizing cell culture systems, animal models and human imaging. Dr. McCabe’s lab is also developing therapeutics to target identified mechanisms and pathways to increase bone formation.
Bibliographic Information
Book Title: Understanding the Gut-Bone Signaling Axis
Book Subtitle: Mechanisms and Therapeutic Implications
Editors: Laura R. McCabe, Narayanan Parameswaran
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-66653-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-66651-8Published: 23 November 2017
Softcover ISBN: 978-3-319-88293-2Published: 09 September 2018
eBook ISBN: 978-3-319-66653-2Published: 02 November 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIII, 277
Number of Illustrations: 7 b/w illustrations, 29 illustrations in colour
Topics: Endocrinology, Human Physiology, Systems Biology
Industry Sectors: Biotechnology, Health & Hospitals, Pharma