Metabolic Disorders and Critically Ill Patients

1. Endocrine Disorders in Intensive Care Unit

   1. Acute Complications of Diabetes

      • Jean-Christophe Orban, Emmanuel Van Obberghen, Carole Ichai

      Pages 341-363

   2. Neuroendocrine Dysfunction in the Critically Ill Patients

      • Antoine Roquilly, Karim Asehnoune

      Pages 365-377

   3. Hyperglycemia in ICU

      • Carole Ichai, Jean-Charles Preiser

      Pages 379-397

2. Energetic Metabolism, Nutrition

   1. Front Matter

      Pages 399-399

      PDF

   2. Nutritional Requirements in Intensive Care Unit

      • Marie-Pier Bachand, Xavier Hébuterne, Stéphane M. Schneider

      Pages 401-419

   3. Pharmaconutrition in the Critically Ill Patient

      • Jean-Charles Preiser, Christian Malherbe, Carlos A. Santacruz

      Pages 421-429

   4. Oxygen and Oxidative Stress

      • Jean-Christophe Orban, Mervyn Singer

      Pages 431-439

   5. Energy Metabolism: From the Organ to the Cell

      • Hervé Quintard, Eric Fontaine, Carole Ichai

      Pages 441-451

   6. Ischemia-Reperfusion Concepts of Myocardial Preconditioning and Postconditioning

      • Pascal Chiari, Stanislas Ledochowski, Vincent Piriou

      Pages 453-467

   7. Targeted Temperature Management in Severe Brain-Injured Patient

      • Hervé Quintard, Alain Cariou

      Pages 469-477

The purpose of this book is to bring together the latest findings on metabolic disorders that are strongly implicated in various critically ill patients. Since the beginning of the 20th century, maintaining the "milieu intérieur" has been a major challenge for intensivists. In addition to considerable technological developments in intensive care units, important advances in our understanding of metabolic disorders observed in critically ill patients have been made during the 10 last years. Today, the intensivit can’t ignore these disorders when selecting the most appropriate treatment for an illness.  Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes  prevention or treatment of such disorders. This book is a  comprehensive tool, allowing the physician to understand, diagnose and treat these metabolic disorders. Water, electrolyte, acid-base, glycemic and endocrinologic problems, as well as metabolic abnormalities observed in renal, cerebral and hepatic failure are presented in different chapters. The last part of the book is devoted to modern nutritional concepts, the consequences of energy modifications, mitochondrial dysfunction, hypothermia, oxidative stress and ischemia reperfusion, which open the way for new therapies.​

• Acid-base disorders
• Acute Renal failure
• Dysnatremias
• Oxidative stress
• Perioperative and ICU Nutrition
• metabolic disease

“With the comprehensive and up-to-date references, readers may readily find further information on specific issues. The text is easy to read and understand. … For those seeking a deeper understanding of metabolic disorders from their pathophysiology to their clinical implications, Metabolic Disorders and Critically Ill Patients will certainly be worth reading. Its appealing didactic structure makes it a valuable tool for teaching and training purposes.” (Ashraf A. Dahaba, Anesthesia & Analgesia, Vol. 127 (3), September, 2018)

• Intensive Care Unit, Hôpital Pasteur 2, Centre Hospitalier Universitaire de Nice, Université Côte d’Azur, Nice, France

  Carole Ichai, Hervé Quintard, Jean-Christophe Orban

Dr Carole Ichai, MD and PhD, is Professor of Anesthesiology and Intensive Care Medicine at the University of Nice and is the head of the medico surgical Intensive Care Unit at the Saint Roch Hospital. She is a Past-member of the scientific and intensive care unit of the French Society of Anesthesiology and Intensive Care Unit (SFAR). She is the Director of the "Sud Méditerranée" European Courses in Anesthesiology and Intensive Care. Her main research interest is all metabolic disturbances and consequences (glycemia disturbances, acid-base water and electrolytes disorders, acute renal failure and hemofiltration) in critically ill patients. Dr Hervé Quintard is a specialist in Anesthesiology and Intensive Care Medicine at the University of Nice and is a full practician of the medico surgical Intensive Care Unit at the Saint Roch Hospital. He is the co-responsible with Pr Ichai of a University Diploma of "Metabolic Intensive Care". His main research interest is in the management and metabolic disturbances of cerebral injury with an experimental research (affiliation in a CNRS laboratory) and a clinical one focused on severe head trauma and sub-arachnoid hemorrhage. Dr Jean-Christophe Orban, PhD, is a specialist in Anesthesiology and Intensive Care Medicine at the University of Nice and is a full practician of the medico surgical Intensive Care Unit at the Saint Roch Hospital. He is the co-responsible with Pr Ichai of a University Diploma of "ICU competences for nurses". His main research interest is in the metabolic consequences of cardiac arrest, therapeutic hypothermia and mitochondrial dysfunction with an experimental research (affiliation in a INSERM laboratory) and a clinical one.

Policies and ethics