© 2017

Pulmonary Vasculature Redox Signaling in Health and Disease

  • Yong-Xiao Wang
  • Written by a collection of international experts in basic and translations research in pulmonary vasculature

  • Comprehensive review of current and emerging developments in the field

  • Provides invaluable information on an important signaling pathway with a critical role in nearly all pulmonary diseases


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 967)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Daniel Hernandez-Saavedra, Kalin Swain, Rubin Tuder, Steen V. Petersen, Eva Nozik-Grayck
    Pages 57-70
  3. Nikki L. Jernigan, Thomas C. Resta, Laura V. Gonzalez Bosc
    Pages 83-103
  4. Manuela Kellner, Satish Noonepalle, Qing Lu, Anup Srivastava, Evgeny Zemskov, Stephen M. Black
    Pages 105-137
  5. Christina M. Pabelick, Michael A. Thompson, Rodney D. Britt Jr
    Pages 179-194
  6. Oleg Pak, Akylbek Sydykov, Djuro Kosanovic, Ralph T. Schermuly, Alexander Dietrich, Katrin Schröder et al.
    Pages 195-225
  7. Lydie Plecitá-Hlavatá, Angelo D’alessandro, Karim El Kasmi, Min Li, Hui Zhang, Petr Ježek et al.
    Pages 241-260
  8. Jesus Prieto-Lloret, Philip I. Aaronson
    Pages 261-276
  9. Megha Sharma, Adeleye J. Afolayan
    Pages 277-287
  10. Yuichiro J. Suzuki, Nataliia V. Shults
    Pages 315-323

About this book


The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field.   

The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.  


reactive oxygen species ROS pulmonary hypertension redox molecules cellular response antioxidant enzymes

Editors and affiliations

  • Yong-Xiao Wang
    • 1
  1. 1.Department of Molecular and Cellular PhysiologyAlbany Medical CollegeAlbanyUSA

About the editors

Dr. Yong-Xiao Wang is a Full Professor in the Department of Molecular and Cellular Physiology at Albany Medical College, Albany, New York, USA. He received his M.D. at the Wannan Medical College (China), Ph.D. at the Fourth Military Medical University (China), and postdoctoral training at the Technical University of Munich (Germany) as well as the University of Pennsylvania (USA). Dr. Wang’s primary research interests have focused on basic, translational, and drug discovery research concerning cardiac arrhythmias and hypertrophy, pulmonary hypertension, asthma, and diabetes for over 30 years. In particular, he has had extensive research experience in the studies of the molecular geneses, regulatory mechanisms, network pathways, physiological functions, and the critical roles of calcium, redox, inflammatory, and other signaling in the aforementioned illnesses. Dr. Wang has been the corresponding author, first author, and key contributor in numerous publications in highly peer-reviewed journals including Antioxid Redox Signal, Proc Natl Acad Sci USA, Free Radic Biol Med, Cell Calcium, J Gen Physiol, J Biol Chem, FASEB J, Nature, Circ Res, and more. He has been the editor of several academic books in the field including a recent one entitled “Calcium Signaling in Airway Smooth Muscle Cells” that was published by Springer in 2014. Dr. Wang has been the principal investigator on multiple research grants and awards from the National Institutes of Health, American Heart Association, American Diabetes Association, and other agencies. He has collaborated with numerous well-known scientists, served on various grant review panels, been the Editor-In-Chief and Editorial Board Member for several scientific journals, and trained a number of scholars, some of whom have become well-known independent investigators in the field.

Bibliographic information

  • Book Title Pulmonary Vasculature Redox Signaling in Health and Disease
  • Editors Yong-Xiao Wang
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-63244-5
  • Softcover ISBN 978-3-319-87507-1
  • eBook ISBN 978-3-319-63245-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XXI, 422
  • Number of Illustrations 16 b/w illustrations, 41 illustrations in colour
  • Topics Human Physiology
    Pneumology/Respiratory System
    Cell Physiology
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