Advertisement

Chromatin Regulation of Early Embryonic Lineage Specification

  • Jason Knott
  • Keith Latham

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 229)

About this book

Introduction

Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages. 

Keywords

extraembryonic primitive endoderm pluripotent epiblast embryonic chromatin structure CHD1 CHD4 H3R26me SOX2-DNA

Editors and affiliations

  • Jason Knott
    • 1
  • Keith Latham
    • 2
  1. 1.Department of Animal ScienceMichigan State UniversityEast LansingUSA
  2. 2.Department of Animal ScienceMichigan State UniversityEast LansingUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-63187-5
  • Copyright Information Springer International Publishing AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-63186-8
  • Online ISBN 978-3-319-63187-5
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site
Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods