Editors:
- Examines the roles of early acting chromatin regulators in ICM and TE formation
- Explores the role of RHOA subfamily of small GTPases and RHO-associated coiled-coil kinases
- Provides an overview on the transcriptional and epigenetic mechanisms that mediate PE lineage formation and XEN cell self-renewal
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 229)
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Table of contents (6 chapters)
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Front Matter
About this book
Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.Â
Editors and Affiliations
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Department of Animal Science, Michigan State University, East Lansing, USA
Jason Knott, Keith Latham
About the editors
Dr. Keith Latham is a developmental biologist with nearly three decades of experience in mammalian embryology. Â His research encompasses epigenetics and imprinting in the early embryo, transcriptional control, translational control, determinants of oocyte quality, and mechanisms underlying meiotic spindle formation and function. Â His research combines the use of diver
se mouse strains, molecular assays applicable to the single cell level, and embryo micromanipulation including different forms of nuclear transfer.
Bibliographic Information
Book Title: Chromatin Regulation of Early Embryonic Lineage Specification
Editors: Jason Knott, Keith Latham
Series Title: Advances in Anatomy, Embryology and Cell Biology
DOI: https://doi.org/10.1007/978-3-319-63187-5
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2018
Softcover ISBN: 978-3-319-63186-8Published: 08 December 2017
eBook ISBN: 978-3-319-63187-5Published: 23 November 2017
Series ISSN: 0301-5556
Series E-ISSN: 2192-7065
Edition Number: 1
Number of Pages: VII, 78
Number of Illustrations: 16 illustrations in colour
Topics: Human Genetics, Cell Biology, Human Physiology
Industry Sectors: Biotechnology, Pharma