Gene-Environment Transactions in Developmental Psychopathology

The Role in Intervention Research

  • Patrick H. Tolan
  • Bennett L. Leventhal

Table of contents

  1. Front Matter
    Pages i-viii
  2. Patrick H. Tolan, Bennett L. Leventhal
    Pages 1-6
  3. Gene-Environment Transaction Framework

  4. Application to Developmental Psychopathology

    1. Front Matter
      Pages 145-145
    2. Richard E. Tremblay, Linda Booij, Nadine Provençal, Moshe Szyf
      Pages 177-207
  5. Intervention Research: Implications for Gene Environment Transaction Framework

  6. Back Matter
    Pages 295-301

About this book


This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. 

Topics featured in this book include: 
  • Epigenetics and the biology of gene x environment interactions.
  • Gene by environment interactions and its potential use for intervention strategies in anxiety disorders.
  • The challenges and potential for research on gene-environment interactions within autism spectrum disorder.
  • Using genetically informed prevention trials to test gene x environment hypothese.
  • Challenges for intervention research within the GEX framework.
Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.


ASD and the GEX framework Anxiety disorders, GEX, and interventions Autism spectrum disorders, GEX, and interventions Biological components and GEX studies De novo mutations and GEX intervention research Dependency and gene-environment interaction Epigenetics and developmental psychopathology GEX framework and developmental psychopathology GEX framework and prevention strategies GEX framework and psychological interventions GEX framework and psychological treatments Gene-environment correlation models Gene-environment transactions and development Intervention-based research Moderation and gene-environment interaction Preventive Interventions and GEX analysis Psychological components and GEX studies Research interventions and GEX Sociological targets for GEX studies

Editors and affiliations

  • Patrick H. Tolan
    • 1
  • Bennett L. Leventhal
    • 2
  1. 1.Youth-Nex CenterUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of PsychiatryUniversity of California at San FranciscoSan FranciscoUSA

Bibliographic information