Sepsis

1. Front Matter

   Pages i-xi

   PDF

2. Part I

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction

      • Mitchell M. Levy, Nicholas S. Ward

      Pages 3-5

   3. Sepsis Definitions

      • Debasree Banerjee, Mitchell M. Levy

      Pages 7-24

   4. Epidemiology of Sepsis: Current Data and Predictions for the Future

      • Bashar Staitieh, Greg S. Martin

      Pages 25-43

3. Part II

   1. Front Matter

      Pages 45-45

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   2. Overview of the Molecular Pathways and Mediators of Sepsis

      • Tristen T. Chun, Brittany A. Potz, Whitney A. Young, Alfred Ayala

      Pages 47-69

   3. Sepsis-Induced Immune Suppression

      • Nicholas Csikesz, Nicholas S. Ward

      Pages 71-87

   4. Molecular Targets for Therapy

      • Andre C. Kalil, Steven M. Opal

      Pages 89-104

4. Part III

   1. Front Matter

      Pages 105-105

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   2. Mechanisms of Organ Dysfunction and Altered Metabolism in Sepsis

      • Douglas R. Closser, Mathew C. Exline, Elliott D. Crouser

      Pages 107-126

   3. Sepsis-Induced AKI

      • Hernando Gomez, Alex Zarbock, Raghavan Murugan, John A. Kellum

      Pages 127-142

   4. Sepsis and the Lung

      • MaryEllen Antkowiak, Lucas Mikulic, Benjamin T. Suratt

      Pages 143-157

   5. Organ Dysfunction in Sepsis: Brain, Neuromuscular, Cardiovascular, and Gastrointestinal

      • Brian J. Anderson, Mark E. Mikkelsen

      Pages 159-183

5. Part IV

   1. Front Matter

      Pages 185-185

      PDF

   2. Diagnosis of Sepsis: Clinical Findings and the Role of Biomarkers

      • Daithi S. Heffernan

      Pages 187-206

   3. Source Control in Sepsis

      • Michael Connolly, Charles Adams

      Pages 207-218

   4. Hemodynamic Support in Sepsis

      • Jean-Louis Vincent

      Pages 219-224

   5. Bundled Therapies in Sepsis

      • Laura Evans, William Bender

      Pages 225-236

   6. Genetics in the Prevention and Treatment of Sepsis

      • John P. Reilly, Nuala J. Meyer, Jason D. Christie

      Pages 237-264

This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured toreview the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.​

• Acute renal failure
• Bundled therapy
• Coagulation system
• Hemodynamic support
• Hyper inflammation
• Organ failure

• Division of Pulmonary Critical Care, and Sleep Medicine, Alpert/Brown Medical School, Providence, USA

  Nicholas S. Ward, Mitchell M. Levy

Dr. Ward joined the Brown faculty in 1999 after completing his pulmonary/critical care training at Yale- New Haven Hospital. His past research interests have included mechanisms of acute lung injury, mechanical ventilation of acute lung injury, and sepsis. His current research focuses on rationing, ethics and ICU resource utilization. In addition to research, Dr. Ward attends in the Medical Intensive Care Unit, the Neuro ICU, and the pulmonary consultation service. He also lectures in the Pulmonary Pathophysiology course and is the co- course director. Dr. Ward is a member of the Medical School curriculum committee, the Rhode Island hospital ethics committee, and is the pulmonary/critical care fellowship director. Dr. Levy is medical director of the Medical Intensive Care Unit at Rhode Island Hospital and professor of medicine and division chief of pulmonary and critical care medicine at The Warren Alpert Medical School of Brown University in Providence, RI. Dr. Levy is a council member of the Society of Critical Care Medicine and is co-chair of the Surviving Sepsis Campaign Management Guidelines Committee. He also serves as a senior editor for the Journal of Critical Care as well as chair of the Robert Wood Johnson Critical Care End-of-Life Work Group, a group he has led since its inception in 1998. Dr. Levy has held leadership positions in the American College of Chest Physicians and the American Thoracic Society. In 2001, Levy chaired the International Educational and Scientific Symposium of the Society of Critical Care Medicine, an organization that also awarded Levy its Award of Ethics and Distinguished Service Award. Upon receiving his medical degree from the University of Buffalo, Levy completed his residency training at the University of Colorado Health System. He is a fellow of the American College of Critical Care Medicine and the American College of Chest Physicians.

Policies and ethics