Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

  • Ulf Grawunder
  • Stefan Barth

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Alex R. Nanna, William R. Roush, Christoph Rader
    Pages 1-28
  3. Hans-Peter Gerber, Marc Damelin, Puja Sapra
    Pages 69-84
  4. Hugh Nymeyer, Douglas A. Lappi, Denise Higgins, Carl E. Noe, Arthur E. Frankel
    Pages 107-130
  5. Theo Thepen, Stefan Barth
    Pages 131-150
  6. Robert J. Kreitman, David J. P. FitzGerald, Ira Pastan
    Pages 151-176
  7. Back Matter
    Pages 177-181

About this book

Introduction

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.


Keywords

Antibody based cancer therapy Antibody drug conjugates (ADC) Immunotoxin development Pyrrolobenzodiazepines Calicheamicin Substance P–Saporin

Editors and affiliations

  • Ulf Grawunder
    • 1
  • Stefan Barth
    • 2
  1. 1.NBE-Therapeutics Ltd.BaselSwitzerland
  2. 2.Faculty of Health SciencesUniversity of Cape TownCape TownSouth Africa

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-46877-8
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-46875-4
  • Online ISBN 978-3-319-46877-8
  • Series Print ISSN 2296-6056
  • Series Online ISSN 2296-6064
  • About this book
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Biotechnology
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