Disordered Vertebral and Rib Morphology in Pudgy Mice

Structural Relationships to Human Congenital Scoliosis

  • Frederic Shapiro

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 221)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Frederic Shapiro
    Pages 1-2
  3. Frederic Shapiro
    Pages 3-6
  4. Frederic Shapiro
    Pages 7-66
  5. Frederic Shapiro
    Pages 67-109
  6. Frederic Shapiro
    Pages 111-113
  7. Back Matter
    Pages 115-123

About this book

Introduction

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

Keywords

congenital scoliosis human vertebral development morphological gradients in deformity spondylocostal dysplasia rib malformation

Authors and affiliations

  • Frederic Shapiro
    • 1
  1. 1.Department of Orthopedic SurgeryChildren's Hospital BostonBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-43151-2
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43149-9
  • Online ISBN 978-3-319-43151-2
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • About this book
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