Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

1. Front Matter

   Pages i-viii

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2. Basic Rules of T Cell Migration

   • Jens V. Stein, Federica Moalli, Markus Ackerknecht

   Pages 1-19

3. Regulation of Anti-tumor T Cell Migration and Function: Contribution of Real-Time Imaging

   • Pierre-Louis Loyher, Christophe Combadière, Alexandre Boissonnas

   Pages 21-49

4. Vascular Normalization, T Cell Trafficking and Anti-tumor Immunity

   • Kellsye L. Fabian, Walter J. Storkus

   Pages 51-76

5. Disruption of Anti-tumor T Cell Responses by Cancer-Associated Fibroblasts

   • Arnaud Pommier, Douglas T. Fearon

   Pages 77-98

6. Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Clinic

   • Bertrand Dubois, Hélène Kaplon, Coline Couillault, Christophe Caux, Marie-Caroline Dieu-Nosjean

   Pages 99-125

7. Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy

   • Joseph M. Cantor

   Pages 127-161

8. Chemokines and T Cell Trafficking into Tumors: Strategies to Enhance Recruitment of T Cells into Tumors

   • Stefano Garetto, Claudia Sardi, Diego Morone, Marinos Kallikourdis

   Pages 163-177

9. Strategies to Enhance Migration and Persistence of Chimeric Antigen Receptor (CAR)-T Cells into Tumors

   • Yuhui Chen, Gianpietro Dotti, Barbara Savoldo

   Pages 179-193

10. Back Matter

    Pages 195-199

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This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

• Cancer Treatment
• Anti-tumor immune response
• Immogenic tumors
• Cancer-associated fibroblasts
• Cancer-associated Tertiary Lymphoid Structures
• Cancer immunotherapy
• Chemokines
• Chimeric antigen receptor

• Institut Cochin INSERM, Université Paris Descartes, Paris, France

  Emmanuel Donnadieu

Emmanuel Donnadieu, Ph.D, is a researcher and team leader of the 'Dynamics of T cell Interactions' group at the Cochin Institute. His recent research include breakthroughs in newly developed methods for following the migration and activation patterns of lymphocytes and other immune cells within tumors.

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