Metabolism in Cancer

1. Front Matter

   Pages i-ix

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2. The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

   • Charlene Brault, Almut Schulze

   Pages 1-22

3. Lactate—An Integrative Mirror of Cancer Metabolism

   • Stefan Walenta, Nadine F. Voelxen, Wolfgang Mueller-Klieser

   Pages 23-37

4. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

   • Evan C. Lien, Costas A. Lyssiotis, Lewis C. Cantley

   Pages 39-72

5. MYC, Metabolic Synthetic Lethality, and Cancer

   • Annie L. Hsieh, Chi V. Dang

   Pages 73-91

6. The Role of pH Regulation in Cancer Progression

   • Alan McIntyre, Adrian L. Harris

   Pages 93-134

7. Metabolic Features of Cancer Treatment Resistance

   • Andrea Viale, Giulio F. Draetta

   Pages 135-156

8. Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome

   • Jan Budczies, Carsten Denkert

   Pages 157-175

9. Imaging of Tumor Metabolism Using Positron Emission Tomography (PET)

   • Ivayla Apostolova, Florian Wedel, Winfried Brenner

   Pages 177-205

10. Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA

    • Christin Zasada, Stefan Kempa

    Pages 207-220

11. Mathematical Modeling of Cellular Metabolism

    • Nikolaus Berndt, Hermann-Georg Holzhütter

    Pages 221-232

12. Ketogenic Diet and Cancer—a Perspective

    • Christopher Smyl

    Pages 233-240

13. Fasting and Caloric Restriction in Cancer Prevention and Treatment

    • Sebastian Brandhorst, Valter D. Longo

    Pages 241-266

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications.Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

• Cancer-specific metabolism
• Glycolysis
• Mitochondria
• Oncogenes
• Lactate

• RWTH University Hospital, Molecular Tumor Biology, Pauwelsstrasse 30, 52074 , Aachen, Germany

  Thorsten Cramer

• Dept. of Hematology and Oncology, Charité, Berlin, Germany

  Clemens A. Schmitt

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