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  • © 2017

Childhood Acute Lymphoblastic Leukemia

Editors:

(view affiliations)
  • Exhaustively reviews current therapeutic strategies and applications of precision medicine in ALL treatment

  • Provides scientists and clinicians with state of the art knowledge to guide their research and clinical management

  • Written by an international multidisciplinary team of authors

Buying options

eBook
USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-39708-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 109.99
Price excludes VAT (USA)
Hardcover Book
USD 159.99
Price excludes VAT (USA)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-ix
  2. Epidemiology and Etiology of Childhood ALL

    • Morten Tulstrup, Ulrik Kristoffer Stoltze, Kjeld Schmiegelow, Jun J. Yang
    Pages 1-27
  3. Clinical Presentation and Prognostic Factors

    • John Moppett, Rachel Dommett
    Pages 29-48
  4. Cytogenetics and Molecular Genetics

    • Christine J. Harrison, Anthony V. Moorman, Claire Schwab, Ilaria Iacobucci, Charles Mullighan
    Pages 61-98
  5. Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Antileukemic Drugs

    • Kjeld Schmiegelow, Inge van der Sluis
    Pages 99-138
  6. Minimal Residual Disease (MRD) Diagnostics: Methodology and Prognostic Significance

    • J. J. M. van Dongen, V. H. J. van der Velden, M. Brüggemann, A. Orfao
    Pages 139-162
  7. First Line Treatment: Current Approach

    • Ajay Vora
    Pages 163-181
  8. Targeted Therapy and Precision Medicine

    • Sarah K. Tasian, Stephen P. Hunger
    Pages 183-200
  9. Cellular Therapy

    • Sara Ghorashian, Persis Amrolia
    Pages 239-254
  10. Relapsed Acute Lymphoblastic Leukemia of Childhood

    • Su Han Lum, Denise Bonney, Vaskar Saha
    Pages 255-297
  11. Developing World Perspective

    • Allen Yeoh
    Pages 323-336
  12. Back Matter

    Pages 337-342

About this book

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy.

Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches.  Supportive care and management of the condition in resource poor countries are also discussed in detail.

This is an indispensable guide for  research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Keywords

  • acute lymphoblastic leukemia
  • pediatrics
  • hematology
  • genetics
  • cytogenetics
  • immunotherapy
  • first-line treatment
  • targeted therapy

Reviews

“The purpose is to provide an in‐depth look at the complex disease of childhood ALL. … a concise resource such as this can be used by many medical professionals such as physicians, advanced practitioners, medical students, and nurses in pediatric oncology. … The information is concise and detailed, which makes it a good resource for expert or advanced practitioners in oncology … .” (Lacie D. Filkins, Doody's Book Reviews, July, 2017)

Editors and Affiliations

  • Department of Paediatric Haemotology, Sheffield Children’s Hospital NHS Trust, University of Sheffield, Sheffield, United Kingdom

    Ajay Vora

About the editor

Professor Ajay Vora is honorary professor of paediatric haematology at University of Sheffield and consultant paediatric haematologist at Sheffield Children’s Hospital. His daily practice involves the care of children with a variety of malignant and non-malignant blood disorders. He has a special interest in childhood leukaemia and cord blood transplantation. He is chair of the UK NCRI childhood leukaemia sub-group and I-BFM ALL committee. He is chief investigator of childhood and infant ALL clinical trials and is involved with several research projects in this area. He is programme director of the Trent Regional Paediatric Haemopoeitic Stem Cell transplant service. 

Bibliographic Information

  • Book Title: Childhood Acute Lymphoblastic Leukemia

  • Editors: Ajay Vora

  • DOI: https://doi.org/10.1007/978-3-319-39708-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • License: CC BY

  • Hardcover ISBN: 978-3-319-39707-8

  • Softcover ISBN: 978-3-319-81947-1

  • eBook ISBN: 978-3-319-39708-5

  • Edition Number: 1

  • Number of Pages: IX, 342

  • Number of Illustrations: 8 b/w illustrations, 30 illustrations in colour

  • Topics: Hematology, Pediatrics, Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buying options

eBook
USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-39708-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 109.99
Price excludes VAT (USA)
Hardcover Book
USD 159.99
Price excludes VAT (USA)