Progress in the Chemistry of Organic Natural Products 102

  • A. Douglas Kinghorn
  • Heinz Falk
  • Simon Gibbons
  • Jun'ichi Kobayashi

Part of the Progress in the Chemistry of Organic Natural Products book series (POGRCHEM, volume 102)

Table of contents

  1. Front Matter
    Pages i-v
  2. Giovanni Appendino
    Pages 1-90
  3. Maria Harizani, Efstathia Ioannou, Vassilios Roussis
    Pages 91-252

About this book

Introduction

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus.
The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Keywords

marine red algae secondary metabolites biological activity protein genase C drug discovery Euphorbia

Editors and affiliations

  • A. Douglas Kinghorn
    • 1
  • Heinz Falk
    • 2
  • Simon Gibbons
    • 3
  • Jun'ichi Kobayashi
    • 4
  1. 1.Div. Medicinal Chemistry & Pharmacognosy, College of PharmacyThe Ohio State UniversityColumbusUSA
  2. 2.Institute of Organic ChemistryJohannes Kepler University LinzLinzAustria
  3. 3.Research Department of Pharmaceutical and Biological ChemistryUCL School of PharmacyLondonUnited Kingdom
  4. 4.Graduate School of Pharmaceutical ScienceHokkaido University SapporoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-33172-0
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-33170-6
  • Online ISBN 978-3-319-33172-0
  • Series Print ISSN 2191-7043
  • Series Online ISSN 2192-4309
  • About this book
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