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Mitochondrial Dysfunction in Neurodegenerative Disorders

  • Amy K. Reeve
  • Eve M. Simcox
  • Michael R. Duchen
  • Doug M. Turnbull

Table of contents

  1. Front Matter
    Pages i-xi
  2. Mitochondria and Neurodegenerative Disease

    1. Front Matter
      Pages 1-1
    2. Eve Michelle Simcox, Amy Katherine Reeve
      Pages 3-30
  3. Mitochondrial Dysfunction: Causes and Effects?

    1. Front Matter
      Pages 31-31
    2. Jonathan Phillips, Hannah Hayhurst, Nichola Zoe Lax
      Pages 33-58
    3. Carlo Viscomi, Anna Ardissone, Massimo Zeviani
      Pages 81-106
    4. Martin Picard, Meagan J. McManus
      Pages 107-137
  4. Functional Consequences of Mitochondrial Dysfunction

    1. Front Matter
      Pages 139-139
    2. James Surmeier, Enrico Zampese, Daniel Galtieri, Paul T. Schumacker
      Pages 141-173
    3. Arnaud Mourier
      Pages 175-191
    4. Alexia Chrysostomou, Doug M. Turnbull
      Pages 219-239
    5. Elsje G. Otten, Diego Manni, Viktor I. Korolchuk
      Pages 255-278
    6. Matthew Nguyen, Ellen Sidransky, Wendy Westbroek
      Pages 279-300
  5. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease

    1. Front Matter
      Pages 301-301
    2. Marijana Aradjanski, Aleksandra Trifunovic
      Pages 303-328
    3. Kim Chisholm, Fabian Peters, Dimitra G. Schiza, Mona Sadeghian, Kenneth Smith
      Pages 329-345
  6. The Future

    1. Front Matter
      Pages 347-347
    2. Amy Katherine Reeve
      Pages 373-376
  7. Back Matter
    Pages 377-380

About this book

Introduction

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. 

Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. 

Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Keywords

Alzheimer's disease Parkinson's disease mitochondrial dysfunction multiple sclerosis neurodegenration neurodegenrative disorder

Editors and affiliations

  • Amy K. Reeve
    • 1
  • Eve M. Simcox
    • 2
  • Michael R. Duchen
    • 3
  • Doug M. Turnbull
    • 4
  1. 1.Newcastle University Medical SchoolWell. Trust Ctr. for Mitochondrial Res.Newcastle upon TyneUnited Kingdom
  2. 2.Newcastle University Medical SchoolWell. Trust Ctr. for Mitochondrial Res.Newcastle upon TyneUnited Kingdom
  3. 3.Cell and Developmental BiologyUniversity College LondonLondonUnited Kingdom
  4. 4.Newcastle University Medical SchoolWell. Trust Ctr. for Mitochondrial Res.Newcastle upon TyneUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-28637-2
  • Copyright Information Springer International Publishing 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-28635-8
  • Online ISBN 978-3-319-28637-2
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology