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Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology

  • Book
  • © 2016

Overview

Editors:
  1. Luigi Pirtoli

    1. University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy

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  2. Giovanni Luca Gravina

    1. Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Antonio Giordano

    1. Department of Biology, Temple University, Philadelphia, USA

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  • Provides the most recent and relevant advances in molecular radiobiology of glioblastoma, and the related possible changes in the clinical setting
  • Written by experts in the field
  • Bridges the gap of knowledge and methodology in approaching RB of GB between basic researchers and clinical investigators
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Clinical Pathology (CCPATH)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Introduction and Background

    • Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano
    Pages 1-11

  3. From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

    1. Front Matter

      Pages 13-13
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    2. The “Radioresistance” of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options

      • Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini
      Pages 15-27

    3. Radiobiological Hints from Clinical Studies

      • Silvia Scoccianti, Riccardo Santoni, Beatrice Detti, Gianluca Ingrosso, Daniela Greto, Giulio Francolini
      Pages 29-40

    4. Chemoradiotherapy: Radiation Total Dose and Fractionation

      • Silvia Chiesa, Mario Balducci, Milena Ferro, Anna Rita Alitto, Vincenzo Valentini
      Pages 41-62

    5. Clinical Evidence and Radiobiological Background of Particle Radiation Therapy

      • Walter Tinganelli, Marco Durante, Alexander Helm
      Pages 63-85

    6. Mathematical Modelling of Radiobiological Parameters

      • Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini, Luigi Pirtoli
      Pages 87-100

    7. Clinical, Pathological, and Molecular Prognostic Parameters in Glioblastoma Patients Undergoing Chemo- and Radiotherapy

      • Paolo Tini, Clelia Miracco, Marzia Toscano, Silvia Palumbo, Sergio Comincini, Giovanni Luca Gravina et al.
      Pages 101-120

    8. Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond

      • Francesca De Felice, Vincenzo Tombolini, Michela Buglione, Daniela Musio, Luca Triggiani, Stefano Maria Magrini
      Pages 121-135

  4. Preclinical Research

    1. Front Matter

      Pages 139-139
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    2. Basic Knowledge of Glioblastoma Radiobiology

      • Monica Mangoni, Mariangela Sottili, Chiara Gerini, Lorenzo Livi
      Pages 139-153

    3. The Immune System and Its Contribution to the Radiotherapeutic Response of Glioblastoma

      • Benjamin Cooper, Ralph Vatner, Encouse Golden, Joshua Silverman, Silvia Formenti
      Pages 155-175

    4. Genetic and Epigenetic Determinants in Tumor Initiation and Progression of Glioblastoma

      • A. Cimini, A. Fidoamore, M. d’Angelo, A. Antonosante, L. Cristiano, E. Benedetti et al.
      Pages 177-187

    5. Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance

      • Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Lorenzo Livi, Monica Mangoni
      Pages 189-207

    6. Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide

      • Marzia Toscano, Silvia Palumbo, Paolo Tini, Clelia Miracco, Giovanni Luca Gravina, Sergio Comincini
      Pages 209-224

    7. miRNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models

      • Silvia Palumbo, G. Belmonte, Paolo Tini, Marzia Toscano, Clelia Miracco, Sergio Comincini
      Pages 225-237

    8. NanoMaterials Technology for Research Radiobiology

      • Elisa Panzarini, Luciana Dini
      Pages 239-252

  5. From Bench to Bedside: Translational Perspectives

    1. Front Matter

      Pages 253-253
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    2. Preclinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods

      • Anita Tandle, Uma Shankavaram, Cody Schlaff, Kevin Camphausen, Andra Krauze
      Pages 255-274
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Keywords

About this book

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 



Reviews

“This is a very detailed monograph on the roles of radiation, immunotherapy, genetic, epigenetic, and chemotherapy in the treatment of Glioblastoma. Biomarkers and molecular mechanisms of GBMs are discussed. … I highly recommend this book to oncologists, neurosurgeons, neurologists, and researchers involved in this perplexing baffling tumor.” (Joseph Grenier, Amazon.com, May, 2018)

Editors and Affiliations

  • University of Siena, Sec. of Radiation Oncology,Dept. of Med., Siena, Italy

    Luigi Pirtoli

  • Dept. of Applied Clinical & Biotech Sci., University of L’Aquila, L’Aquila, Italy

    Giovanni Luca Gravina

  • Department of Biology, Temple University, Philadelphia, USA

    Antonio Giordano

About the editors

Dr. Luigi PirtoliRadiation Oncology Unit
Department of Medicine, Surgery and Neurosciences
University of Siena
Siena, Italy


Dr. Giovanni Luca Gravina
Department of Biology and Biotechnology
University of Pavia
Rome, Italy


Antonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology
Temple University
Philadelphia, PA, USA
Department of Medicine, Surgery & Neurosciences
University of Siena
Siena, Italy

Bibliographic Information

  • Book Title: Radiobiology of Glioblastoma

  • Book Subtitle: Recent Advances and Related Pathobiology

  • Editors: Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano

  • Series Title: Current Clinical Pathology

  • DOI: https://doi.org/10.1007/978-3-319-28305-0

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-28303-6Published: 16 June 2016

  • Softcover ISBN: 978-3-319-80321-0Published: 30 May 2018

  • eBook ISBN: 978-3-319-28305-0Published: 06 June 2016

  • Series ISSN: 2197-781X

  • Series E-ISSN: 2197-7828

  • Edition Number: 1

  • Number of Pages: XX, 305

  • Number of Illustrations: 10 b/w illustrations, 39 illustrations in colour

  • Topics: Pathology, Oncology

  • Industry Sectors: Biotechnology, Finance, Business & Banking, Health & Hospitals, Pharma

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