System Engineering Approach to Planning Anticancer Therapies

  • Andrzej Świerniak
  • Marek Kimmel
  • Jaroslaw Smieja
  • Krzysztof Puszynski
  • Krzysztof Psiuk-Maksymowicz

Table of contents

  1. Front Matter
    Pages i-ix
  2. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 1-8
  3. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 9-54
  4. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 55-83
  5. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 85-138
  6. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 139-169
  7. Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz
    Pages 171-198
  8. Back Matter
    Pages 199-235

About this book

Introduction

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. 

The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors’ extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

Keywords

biomathematical modelling anticancer therapies structure models signalling pathway dynamics population dynamics optimimzation cell cycle drug resistance 93A30; 92C42, 49N90, 92D25, 37N25, 92C50, 93C95, 35Q92, 93B35.

Authors and affiliations

  • Andrzej Świerniak
    • 1
  • Marek Kimmel
    • 2
  • Jaroslaw Smieja
    • 3
  • Krzysztof Puszynski
    • 4
  • Krzysztof Psiuk-Maksymowicz
    • 5
  1. 1.Institute of Automatic ControlSilesian University of TechnologyGliwicePoland
  2. 2.Rice UniversityHoustonUSA
  3. 3.Institute of Automatic ControlSilesian University of TechnologyGliwicePoland
  4. 4.Institute of Automatic ControlSilesian University of TechnologyGliwicePoland
  5. 5.Institute of Automatic ControlSilesian University of TechnologyGliwicePoland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-28095-0
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-3-319-28093-6
  • Online ISBN 978-3-319-28095-0
  • About this book
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