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  • © 2016

Intraoperative Ultrasound (IOUS) in Neurosurgery

From Standard B-mode to Elastosonography

  • Helps the reader to make optimal use of IOUS for imaging guidance during cranial and spinal neurosurgical procedures

  • Explains the impact of recent technical advances

  • Offers guidance on the interpretation of imaging findings

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eBook USD 59.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-25268-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 79.99
Price excludes VAT (USA)
Hardcover Book USD 109.99
Price excludes VAT (USA)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xxi
  2. General Aspects

    1. Front Matter

      Pages 1-1
    2. Clinical Ultrasound: Historical Aspects

      • Prakash Shetty, Aliasgar V. Moiyadi
      Pages 3-8
    3. US Physics, Basic Principles, and Clinical Application

      • Alberto Martegani, Luca Mattei, Luca Aiani
      Pages 9-17
  3. B-Mode Ultrasound

    1. Front Matter

      Pages 19-19
    2. Ultrasound System Setup and General Semeiology

      • Luca Maria Sconfienza, Giovanni Mauri, Francesco Secchi
      Pages 21-28
    3. Echographic Brain Semeiology and Topographic Anatomy According to Surgical Approaches

      • Francesco Prada, Massimiliano Del Bene, Alessandro Moiraghi, Francesco DiMeco
      Pages 29-39
    4. Intraoperative Findings in Brain Tumor Surgery

      • Jan Coburger, Ralph W. König
      Pages 41-58
    5. Intraoperative Findings in Spinal Lesions

      • Ignazio G. Vetrano, Francesco Prada
      Pages 59-69
    6. Intraoperative Findings in Peripheral Nerve Pathologies

      • Ralph W. Koenig, Jan Coburger, Maria Teresa Pedro
      Pages 71-79
    7. Multimodal Imaging in Glioma Surgery

      • Andrej Šteňo, Carlo Giussani, Matteo Riva
      Pages 81-97
  4. Doppler Imaging

    1. Front Matter

      Pages 99-99
    2. Doppler Imaging: Basic Principles and Clinical Application

      • Valentina Caldiera, Luigi Caputi, Elisa Ciceri
      Pages 101-120
  5. Intra-operative Ultrasound, Fusion Imaging and Virtual Navigation

    1. Front Matter

      Pages 121-121
    2. Virtual Navigation and Interventional Procedures

      • Giovanni Mauri, Luigi Solbiati
      Pages 123-134
    3. Navigable Ultrasound, 3D Ultrasound and Fusion Imaging in Neurosurgery

      • Aliasgar V. Moiyadi, Geirmund Unsgård
      Pages 135-145
  6. Contrast Enhanced Ultrasound (CEUS)

    1. Front Matter

      Pages 147-147
    2. Contrast-Enhanced Ultrasound: Basic Principles, General Application, and Future Trends

      • Marcello Caremani, Carla Richetta, Daniela Caremani
      Pages 149-158
    3. Contrast-Enhanced Ultrasound (CEUS) in Neurosurgery

      • Francesco Prada, Massimiliano Del Bene, Francesco DiMeco
      Pages 159-169
  7. Elastosonography

    1. Front Matter

      Pages 171-171

About this book

This book is intended as a practical manual on the use of intraoperative ultrasound (IOUS) as a tool for imaging guidance during cranial and spinal neurosurgical procedures. Full account is taken of the emergence of novel clinical applications and recent technical advances, with extensive coverage of the impact of developments such as improved probe technology, fusion imaging and virtual navigation, 3D ultrasound imaging, contrast-enhanced ultrasound, and elastosonography. Basic principles of ultrasound are elucidated in order to assist in the optimal use of IOUS and clear guidance is provided on the interpretation of imaging findings in various pathologies. Informative comparisons are also made of the use of techniques such as fusion imaging and contrast-enhanced ultrasound in general radiology and neurosurgery. The aim of the authors is to enhance the general knowledge regarding intra-operative ultrasound brain imaging, standardizing its use and exploring new techniques, leading in some way toward compensating the lack of specific training in the application of ultrasound among the neurosurgical community. IOUS is a sensitive tool that can improve surgical precision and help to reduce morbidity.


  • Brain surgery
  • Brain tumor
  • Fusion imaging
  • Image guidance
  • Contrast-enhanced ultrasound


“This is a well-illustrated monograph of 200 pages on 2D, 3D, Doppler, B-Mode Elastography, and Ultrasound imaging of gliomas, aneurysms, AVMs, and other vascular anomalies. … The book is richly illustrated with full color pictures. … This is essential reading material for all neurosurgeons using ultrasound.” (Joseph J. Grenier,, July, 2016)

Editors and Affiliations

  • Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy

    Francesco Prada

  • UO Radiologia Oncologica, Humanitas Univ. and Research Hospital UO Radiologia Oncologica, Busto Arsizio, Italy

    Luigi Solbiati

  • UO Radiologia, Ospedale Valduce, Como, Como, Italy

    Alberto Martegani

  • Istituto Neurologico C. Besta, Fondazione IRCCS, Milano, Italy

    Francesco DiMeco

About the editors

Francesco Prada is staff neurosurgeon in the 1st Neurosurgical Division of the Department of Neurosurgery at the Fondazione IRCCS Istituto Neurologico C.Besta in Milan, Italy, where he received his surgical training with professor S. Giombini, before starting to work under Professor F. DiMeco's guidance, developing his interest between clinical practice and research focusing on skull base surgery and neuro-oncology. He is currently leading the “Intra-operative Ultrasound in Neurosurgery Project”, started in 2009, and has infact performed more than 500 image guided ultrasound procedures. He particularly focuses on the intra-operative applications of ultrasound for the treatment of cerebral and spinal tumor and vascular lesions. He is currently developing advanced ultrasound techniques in neurosurgery, such as Fusion Imaging for Virtual Navigation, contrast enhanced ultrasound (CEUS) and elastosonography. His interest for diagnostic and therapeutic US applications lead to his involvement in the "TheraGlio" project, aimed at the development of multimodal contrast agents. He has further interest in alpinism and has obtained the diploma in mountain medicine of the “Union Internationale des Associations d’Alpinisme”: he is currently investigating the physiopathological mechanism of cerebral edema in high altitude mountain sickness. Dr. Prada has published 36 original articles in peer-reviewed journals and 2 chapters in textbooks of Neurosurgery and has been Editor and Reviewer of numerous scientific publications. He has given presentations and lectures at national and international meetings.

Luigi A. Solbiati was Chairman of the Department of Oncology and Head of the Division of Interventional Oncologic Radiology at the Hospital of Busto Arsizio (Milan area, Italy) for 13 years and has been Contract Professor of Techniques and Methods of Diagnostic Imaging at the University of Milan since 1988. In July 2015 he became Professor of Radiology at Humanitas University and Research Hospital in Milan. His main fields of interest have always been small parts ultrasound, interventional procedures in oncologic diseases (particularly tumor ablation), imaging of the neck and contrast-enhanced sonography. He was one of the pioneers of ultrasound-guided aspiration biopsies (1979), ethanol injection of solid tumors (1983) and fusion imaging for the guidance of interventional procedures (2003). He has one of the largest world experiences in the treatment of liver malignancies with radiofrequency ablation (RFA) and, more recently, high-power microwaves, accounting for more than 2,200 patients. Prof. Solbiati has published 112 original articles in peer-reviewed journals and 81 chapters in textbooks of Radiology, Interventional Radiology and Oncology and has been Editor of 11 books on small-parts sonography, contrast-enhanced sonography and ablative therapies. He has given more than 550 presentations at Meetings in 36 different countries. In 2006 Prof. Solbiati chaired the 1st  World Conference on Interventional Oncology (Cernobbio, Italy) and in 2013 the 1st Interventional Oncology Sans Frontieres Congress (IOSFC) (Cernobbio, Italy). His H-index is currently 41, his impact factor exceeds 400 and his publications had more than 10,800 citations.

Bibliographic Information

  • Book Title: Intraoperative Ultrasound (IOUS) in Neurosurgery

  • Book Subtitle: From Standard B-mode to Elastosonography

  • Editors: Francesco Prada, Luigi Solbiati, Alberto Martegani, Francesco DiMeco

  • DOI:

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-25266-7

  • Softcover ISBN: 978-3-319-79759-5

  • eBook ISBN: 978-3-319-25268-1

  • Edition Number: 1

  • Number of Pages: XXI, 187

  • Number of Illustrations: 45 b/w illustrations, 107 illustrations in colour

  • Topics: Interventional Radiology, Neurosurgery, Radiology, Neurology, Oncology

  • Industry Sectors: Health & Hospitals, Pharma

Buying options

eBook USD 59.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-25268-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 79.99
Price excludes VAT (USA)
Hardcover Book USD 109.99
Price excludes VAT (USA)