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The Initiation of DNA Replication in Eukaryotes

  • Daniel L. Kaplan

Table of contents

  1. Front Matter
    Pages i-xii
  2. Nalini Dhingra, Daniel L. Kaplan
    Pages 1-21
  3. Mónica P. Gutiérrez, David M. MacAlpine
    Pages 87-104
  4. Conrad A. Nieduszynski
    Pages 105-122
  5. M. K. Raghuraman, Ivan Liachko
    Pages 123-141
  6. Naoko Yoshizawa-Sugata, Satoshi Yamazaki, Hisao Masai
    Pages 143-158
  7. Timothy Hoggard, Catherine A. Fox
    Pages 159-188
  8. Alberto Riera, Christian Speck
    Pages 189-211
  9. Johanna Paik, Serena Giovinazzi, Akash Gunjan
    Pages 213-237
  10. Seiji Tanaka, Hiroyuki Araki
    Pages 263-278
  11. Daniel Rossbach, Robert A. Sclafani
    Pages 279-296
  12. Karl-Uwe Reußwig, Dominik Boos, Boris Pfander
    Pages 297-318
  13. Ryan M. Baxley, Yee Mon Thu, Anja-Katrin Bielinsky
    Pages 319-341
  14. Giacomo De Piccoli, Agnieszka Gambus
    Pages 343-370
  15. Helmut Pospiech, Anna Szambowska
    Pages 393-409
  16. Barbara Medagli, Patrizia Di Crescenzio, Matteo De March, Silvia Onesti
    Pages 411-425
  17. Jingchuan Sun, Zuanning Yuan, Bruce Stillman, Christian Speck, Huilin Li
    Pages 427-441
  18. Kerstin Köhler, Pedro Ferreira, Boris Pfander, Dominik Boos
    Pages 443-460
  19. Michael J. R. Stark, Shin-ichiro Hiraga, Anne D. Donaldson
    Pages 461-477
  20. Nanda Kumar Sasi, Michael Weinreich
    Pages 479-502
  21. Manzar Hossain, Bruce Stillman
    Pages 503-524
  22. Roberto A. Donnianni, Lorraine S. Symington
    Pages 525-545
  23. Back Matter
    Pages 547-563

About this book

Introduction

​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells.  The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur.  Errors in DNA replication can lead to genome instability and cancer.  The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process.  A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings.  The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity.  This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.   It is the cellular protein machinery that enables replication initiation to be activated and regulated.  We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Keywords

cellular dna eukaryotes genetics replication

Editors and affiliations

  • Daniel L. Kaplan
    • 1
  1. 1.Florida State Univ. College of MediTALLAHASSEEUSA

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