Editors:
- Unique focus, as there is a dearth of material with a specific focus on HPV-associated oropharyngeal squamous cell carcinoma
- Topical, due to an increase of greater than 200% in cases of HPV-positive oropharyngeal cancer between 1984 and 2004
- Approaches the subject from multiple perspectives, with an emphasis on virology
- Includes supplementary material: sn.pub/extras
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries.  In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.
This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
Editors and Affiliations
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School of Medicine, University of Missouri, Columbia, USA
Daniel L. Miller
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Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, USA
M. Sharon Stack
Bibliographic Information
Book Title: Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer
Editors: Daniel L. Miller, M. Sharon Stack
DOI: https://doi.org/10.1007/978-3-319-21100-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-21099-5Published: 11 August 2015
Softcover ISBN: 978-3-319-35478-1Published: 22 October 2016
eBook ISBN: 978-3-319-21100-8Published: 01 August 2015
Edition Number: 1
Number of Pages: VIII, 314
Number of Illustrations: 7 b/w illustrations, 22 illustrations in colour
Topics: Virology, Cancer Research, Immunology, Medical Microbiology
Industry Sectors: Biotechnology, Pharma