The Smoothened Receptor in Cancer and Regenerative Medicine

  • Martial Ruat

Part of the Topics in Medicinal Chemistry book series (TMC, volume 16)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Martial Ruat, Lucile Hoch
    Pages 1-11
  3. Qing Shi, Jin Jiang
    Pages 109-125
  4. Martial Ruat, Hélène Faure, Mathieu Daynac
    Pages 147-171
  5. Raffaella Soleti, Ramaroson Andriantsitohaina, Maria Carmen Martínez
    Pages 173-205
  6. Back Matter
    Pages 207-210

About this book


Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.


Agonists Allosteric Modulators Antagonists G-proteins GPCRs Hedgehog Regulation Hedgehog Signaling Medulloblastoma Neovascularization Pharmaco Chemistry

Editors and affiliations

  • Martial Ruat
    • 1
  1. 1.Institute of Neurosciences Paris-Saclay (Neuro-PSI)National Centre for Scientific ResearchGif-YvetteFrance

Bibliographic information

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