The Vertebrate Blood-Gas Barrier in Health and Disease

Structure, Development and Remodeling

  • Andrew N. Makanya

Table of contents

  1. Front Matter
    Pages i-xiv
  2. David C. Budd, Victoria J. Burton, Alan M. Holmes
    Pages 65-84
  3. Panfeng Fu, Viswanathan Natarajan
    Pages 85-113
  4. Charles A. Downs, My N. Helms
    Pages 115-133
  5. Holger C. Müller-Redetzky, Jasmin Lienau, Martin Witzenrath
    Pages 159-187
  6. Anke Schnapper, Matthias Ochs
    Pages 189-220
  7. Back Matter
    Pages 241-243

About this book


This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation.

Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the  BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the  BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.


BGB Fluid Transport Function Lung Injury pneumology

Editors and affiliations

  • Andrew N. Makanya
    • 1
  1. 1.Department of Veterinary Anatomy and PhysiologyUniversity of NairobiNairobiKenya

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