Editors:
The first book to give the blood-gas barrier a holistic approach; from basic structure to development, pathology and treatment
Covers the broad scope of the vertebrata, while laying emphasis on humans
Emphasizes the current trends, especially the molecular biology of the topics
Includes supplementary material: sn.pub/extras
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation.
Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the  BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the  BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.
Editors and Affiliations
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Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya
Andrew N. Makanya
About the editor
About the Editor
Dr. Andrew N Makanya received his MSc and PhD from the University of Nairobi in Nairobi, Kenya, and his Doctor of Veterinary Medicine from the University of Bern in Bern, Switzerland. He is Senior Lecturer in the Department of Veterinary Anatomy and Physiology at the University of Nairobi and is a practicing veterinary surgeon. His research interests include lung development and function, angiogenesis, and differentiation and remodeling of the blood-gas barrier, and he has published widely in these areas. Dr. Makanya is also chairman of the Board of Governors of two secondary schools in Kenya, and participates actively in community development programs focusing on schools, churches, and children’s homes.
Bibliographic Information
Book Title: The Vertebrate Blood-Gas Barrier in Health and Disease
Book Subtitle: Structure, Development and Remodeling
Editors: Andrew N. Makanya
DOI: https://doi.org/10.1007/978-3-319-18392-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-18391-6Published: 08 September 2015
Softcover ISBN: 978-3-319-35553-5Published: 22 October 2016
eBook ISBN: 978-3-319-18392-3Published: 27 August 2015
Edition Number: 1
Number of Pages: XIV, 243
Number of Illustrations: 32 b/w illustrations, 23 illustrations in colour
Topics: Human Physiology, Pneumology/Respiratory System, Angiology
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma