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Apolipoprotein Mimetics in the Management of Human Disease

  • G.M. Anantharamaiah
  • Dennis Goldberg

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Jere P. Segrest
    Pages 1-13
  3. Mohamad Navab, Srinivasa T. Reddy, David Meriwether, Spencer I. Fogelman, Alan M. Fogelman
    Pages 15-27
  4. Dan Li, Scott Gordon, Anna Schwendeman, Alan T. Remaley
    Pages 29-42
  5. Max Benson, Stephen J. Peterson, Parag Mehta, Nader G. Abraham
    Pages 43-54
  6. Robin Farias-Eisner, Feng Su, G. M. Anantharamahiah, Mohamad Navab, Alan M. Fogelman, Srinivasa T. Reddy
    Pages 55-62
  7. Oleg F. Sharifov, G. M. Anantharamaiah, Himanshu Gupta
    Pages 63-88
  8. Samantha Giordano, Philip Kramer, Victor M. Darley-Usmar, C. Roger White
    Pages 99-118
  9. David W. Garber, Dennis Goldberg, G. M. Anantharamaiah
    Pages 135-156
  10. Michael P. Vitek, Fengqiao Li, Carol A. Colton
    Pages 157-182

About this book

Introduction

This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimer’s disease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer.

Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases.

The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book

Keywords

Alzheimer's disease Apolipoprotein mimetics Atherosclerosis Diabetes Lipid-mediated disorders Short mimetic peptides

Editors and affiliations

  • G.M. Anantharamaiah
    • 1
  • Dennis Goldberg
    • 2
  1. 1.Department of MedicineUniversity of Alabama School of MedicineBirminghamUSA
  2. 2.LipimetiX Development, LLCNatickUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-17350-4
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Adis, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-17349-8
  • Online ISBN 978-3-319-17350-4
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology