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Biomolecular Interfaces

Interactions, Functions and Drug Design

  • Ariel Fernández Stigliano

Table of contents

  1. Front Matter
    Pages i-xix
  2. Ariel Fernández Stigliano
    Pages 243-258
  3. Back Matter
    Pages 331-372

About this book

Introduction

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior.

The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Keywords

Biological water Biomolecular interface Chemical physics Drug design Hydrogen bond Molecular biophysics Protein interactions

Authors and affiliations

  • Ariel Fernández Stigliano
    • 1
  1. 1.National Research Council - CONICETBuenos AiresArgentina

Bibliographic information

Industry Sectors
Pharma
Biotechnology