Stem Cell Biology in Neoplasms of the Central Nervous System

  • Moneeb Ehtesham

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 853)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Vivian Capilla-Gonzalez, Emily Lavell, Alfredo Quiñones-Hinojosa, Hugo Guerrero-Cazares
    Pages 1-21
  3. Branavan Manoranjan, Neha Garg, David Bakhshinyan, Sheila K. Singh
    Pages 49-68
  4. Imad Saeed Khan, Moneeb Ehtesham
    Pages 69-83
  5. Anthony E. Rizzo, Jennifer S. Yu
    Pages 85-110
  6. Mia Dahl Sørensen, Sigurd Fosmark, Sofie Hellwege, Dagmar Beier, Bjarne Winther Kristensen, Christoph Patrick Beier
    Pages 111-138
  7. Mecca Madany, Tom M. Thomas, Lincoln Edwards, John S. Yu
    Pages 139-166
  8. Back Matter
    Pages 189-190

About this book


This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.
The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.


CSCs brain tumor neuro stem cell research neuro-oncology tumor stem cells

Editors and affiliations

  • Moneeb Ehtesham
    • 1
  1. 1.Department of NeurosurgeryVanderbilt University Medical CenterNashvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-16536-3
  • Online ISBN 978-3-319-16537-0
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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