Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells

Mathematical Modeling and Experimental Observations

  • Iman┬áTavassoly

Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

Keywords

Apoptosis Autophagy Cell Death Live Cell Imaging Quantitative Fluorescence Microscopy Systems Biology

Authors and affiliations

  • Iman┬áTavassoly
    • 1
  1. 1.Program of Genetics, Bioinformatics and Computational Biology (GBCB)Virginia Polytechnic Institute and State UniversityBlacksburgUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-14962-2
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-14961-5
  • Online ISBN 978-3-319-14962-2
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book
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