Extreme Hepatic Surgery and Other Strategies

Increasing Resectability in Colorectal Liver Metastases

  • Eduardo de Santibañes
  • Victoria Ardiles
  • Fernando A. Alvarez
  • Virginia Cano Busnelli
  • Martin de Santibañes

Table of contents

  1. Front Matter
    Pages i-xix
  2. Global Patient Evaluation and Oncological Assessment

    1. Front Matter
      Pages 1-1
    2. Henri Bismuth, Ruben Balzarotti, Pietro Majno
      Pages 3-18
    3. Anthe Sterkenburg, Jan Müller, Marc-André Weber, Peter Schemmer
      Pages 19-30
    4. Kasia P. Cieslak, Roelof J. Bennink, Thomas M. van Gulik
      Pages 31-52
    5. Jens Mittler, Roman Klöckner, Hauke Lang
      Pages 53-64
    6. Victoria Ardiles, Eduardo de Santibañes
      Pages 65-75
  3. Non-operative Multimodal Therapies

    1. Front Matter
      Pages 77-77
    2. Jorge Pablo Grondona
      Pages 79-118
    3. Kristoffer Watten Brudvik, Jean-Nicolas Vauthey
      Pages 119-130
    4. Rohit Chandwani, Michael I. D’Angelica
      Pages 131-142
    5. Ricardo Garcia-Mónaco
      Pages 143-155
  4. Surgical Strategies

    1. Front Matter
      Pages 157-157
    2. Francisco Carlos Bonofiglio
      Pages 159-175
    3. Guido Torzilli, Guido Costa, Fabio Procopio, Luca Viganó, Matteo Donadon
      Pages 177-193
    4. Ulrich Bork, Nuh N. Rahbari, Christoph Reissfelder, Sören Torge Mees, Jürgen Weitz
      Pages 195-202
    5. Katsunori Imai, René Adam
      Pages 203-215
    6. Michael Linecker, Henrik Petrowsky, Pierre-Alain Clavien
      Pages 217-230
    7. Fernando A. Alvarez, Eduardo de Santibañes
      Pages 231-247
    8. Alessandro Ferrero, Roberto Lo Tesoriere, Serena Langella, Nadia Russolillo
      Pages 249-264

About this book

Introduction

This book describes the diagnoses; staging and management of patients with colorectal liver metastases initially considered unresectable and portrays the different strategies to increase resectability along with their tactics and tricks. Colorectal carcinoma is the third most commonly diagnosed cancer in the world and according to recent cancer statistics around 1.23 million patients are diagnosed each year. Of these patients, approximately 50% will develop liver metastases during the course of their disease and around 15-25% are found to have stage IV disease at diagnosis. Liver resection has been recognized as the treatment of choice for these patients, offering overall 5-year survival rates of up to 50-60% and the only hope for cure. However, at diagnosis only 10-20% of these patients are possibly amenable to surgical resection with curative intent. The possibility to achieve an R0 resection is many times limited by the amount and quality of the future liver remnant (FLR), being posthepatectomy liver failure (PHLF) the most feared and severe complication after major liver resections. With the years, diverse strategies have been developed with the intention to increase resectability by increasing the future liver remnant and/or reducing tumor size, e.g. ALPPS. Along with these techniques, associated surgeries are developed including multivisceral resections, which broadens even more the resectability for patients.

Keywords

ALPPS Colorectal liver metastasis Ex situ ressection Liver oncology Liver surgery

Editors and affiliations

  • Eduardo de Santibañes
    • 1
  • Victoria Ardiles
    • 2
  • Fernando A. Alvarez
    • 3
  • Virginia Cano Busnelli
    • 4
  • Martin de Santibañes
    • 5
  1. 1.General Surgery Department HPB and Liver Transplant UnitHospital Italiano de Buenos AiresBuenos AiresArgentina
  2. 2.General Surgery Department HPB and Liver Transplant UnitHospital Italiano de Buenos AiresBuenos AiresArgentina
  3. 3.General Surgery Department HPB and Liver Transplant UnitHospital Italiano de Buenos AiresBuenos AiresArgentina
  4. 4.General Surgery Department HPB and Liver Transplant UnitHospital Italiano de Buenos AiresBuenos AiresArgentina
  5. 5.General Surgery Department HPB and Liver Transplant UnitHospital Italiano de Buenos AiresBuenos AiresArgentina

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-13896-1
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-13895-4
  • Online ISBN 978-3-319-13896-1
  • About this book
Industry Sectors
Pharma