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Receptor Tyrosine Kinases: Family and Subfamilies

  • Deric L. Wheeler
  • Yosef Yarden

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Ruth H. Palmer, Bengt Hallberg
    Pages 1-51
  3. Greg Lemke
    Pages 53-77
  4. Birgit Leitinger
    Pages 79-106
  5. Fresia Pareja, Gur Pines, Yosef Yarden
    Pages 107-164
  6. Thomas Gaitanos, Irina Dudanova, Maria Sakkou, Rüdiger Klein, Sónia Paixão
    Pages 165-264
  7. Abbie E. Fearon, Athina-Myrto Chioni, Richard P. Grose
    Pages 265-295
  8. Rive Sarfstein, Haim Werner
    Pages 297-320
  9. ChongFeng Gao, George F. Vande Woude
    Pages 321-358
  10. Steven J. Burden, Stevan R. Hubbard, Wei Zhang, Norihiro Yumoto
    Pages 359-372
  11. Violeta Chitu, Cristina I. Caescu, E. Richard Stanley, Johan Lennartsson, Lars Rönnstrand, Carl-Henrik Heldin
    Pages 373-538
  12. Anne-Catherine Lhoumeau, Sébastien Martinez, Thomas Prébet, Jean-Paul Borg
    Pages 539-558
  13. Rosa Marina Melillo, Massimo Santoro
    Pages 559-591
  14. Mitsuharu Endo, Michiru Nishita, Ryosuke Doi, Makoto Hayashi, Yasuhiro Minami
    Pages 593-640
  15. Alain Charest
    Pages 641-684
  16. Michael M. Halford, Maria L. Macheda, Steven A. Stacker
    Pages 685-741
  17. Pipsa Saharinen, Michael Jeltsch, Mayte M. Santoyo, Veli-Matti Leppänen, Kari Alitalo
    Pages 743-775
  18. Hubert Hondermarck, Yohann Demont, Ralph A. Bradshaw
    Pages 777-820
  19. Guanglei Zhuang, Napoleone Ferrara
    Pages 821-841
  20. Li Liu
    Pages 843-859
  21. Back Matter
    Pages 861-878

About this book

Introduction

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Family and Subfamilies systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the fifty-eight RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, which refers to specific subfamilies of RTKs, along with their unique landmarks.

Keywords

FGFR downstream signaling pathways human disease receptor family receptor systems

Editors and affiliations

  • Deric L. Wheeler
    • 1
  • Yosef Yarden
    • 2
  1. 1.School of Medicine and Public Health Department of Human OncologyUniversity of WisconsinMadisonUSA
  2. 2.Department of Biological RegulationRehovotIsrael

Bibliographic information

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