Targeting the Broadly Pathogenic Kynurenine Pathway

  • Sandeep Mittal

Table of contents

  1. Front Matter
    Pages i-xv
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Sharon K. Michelhaugh, Anthony R. Guastella, Sandeep Mittal
      Pages 3-9
    3. Katsumi Shibata
      Pages 31-43
    4. Trevor W. Stone, Caroline M. Forrest, L. Gail Darlington
      Pages 45-61
    5. Daniela Ramirez Ortega, Dinora González Esquivel, Benjamín Pineda, Camilo Ríos, Verónica Pérez de la Cruz
      Pages 63-74
    6. Johanna M. Gostner, Kathrin Becker, Barbara Sperner-Unterweger, Florian Überall, Dietmar Fuchs, Barbara Strasser
      Pages 75-89
  3. Systemic Diseases

    1. Front Matter
      Pages 91-91
    2. Adam P. Cribbs, Richard O. Williams
      Pages 93-107
    3. Hirokazu Kawasaki, Shau-Ku Huang
      Pages 109-119
    4. Jean-Pierre Routy, Vikram Mehraj, Kishanda Vyboh
      Pages 121-131
    5. Harald Mangge, Eva Reininghaus, Dietmar Fuchs
      Pages 133-143
    6. David M. Alvarado, Srikanth Santhanam, Matthew A. Ciorba
      Pages 157-167
    7. Silvia Kathrin Eller, Walter Däubener
      Pages 179-190
  4. CNS Disorders

    1. Front Matter
      Pages 191-191
    2. Zsófia Majláth, József Toldi, László Vécsei
      Pages 193-204
    3. Monika Sharma, Chaitali Anand, Diane C. Chugani
      Pages 205-213
    4. Heidi Ormstad, Robert Verkerk
      Pages 215-232
    5. Zsófia Majláth, József Toldi, László Vécsei
      Pages 233-240
    6. Brian M. Campbell, Ana Pocivavsek, Francesca M. Notarangelo, Anna I. Parachikova
      Pages 241-254
  5. Oncology

    1. Front Matter
      Pages 255-255
    2. Simon P. Jones, Gilles J. Guillemin, Bruce J. Brew
      Pages 257-272
    3. Christopher G. Mowat
      Pages 273-286
    4. Sharon K. Michelhaugh, Kaushik Varadarajan, Anthony R. Guastella, Sandeep Mittal
      Pages 287-295
    5. Sarah Parisi, Antonio Curti
      Pages 297-305
  6. Experimental Models and In Vivo Imaging

    1. Front Matter
      Pages 307-307
    2. Anthony R. Guastella, Sharon K. Michelhaugh, Sandeep Mittal
      Pages 309-322
    3. Paul Cumming, Per Hartvig-Honoré
      Pages 339-355
    4. Otto Muzik, Sandeep Mittal, Csaba Juhász
      Pages 357-372
    5. Csaba Juhász, Sandeep Mittal
      Pages 373-389
  7. Therapeutic Approaches

    1. Front Matter
      Pages 391-391
    2. Melanie Sheen, Hatem Soliman
      Pages 407-417
    3. Chai K. Lim, Gilles J. Guillemin
      Pages 419-425
  8. Back Matter
    Pages 427-430

About this book


This book highlights the known associations between the kynurenine pathway and various disease states and also examines the current state of drug development and clinical trials of compounds known to alter tryptophan metabolism. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It explores the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.


This book also:


·         Combines basic understanding of the role of the kynurenine pathway with translational applications and clinical relevance

·         Explains the role of the kynurenine pathway in various disease states

·         Explores ongoing clinical trials using IDO/TDO inhibitors


Indoleamine-2,3-dioxygenase Inflammation and cardiovascular disease Kynurenine pathway Tryptophan metabolism neurodegenerative diseases tryptophan-2,3-dioxygenase

Editors and affiliations

  • Sandeep Mittal
    • 1
  1. 1.Chairman, Department of NeurosurgeryWayne State UniversityDetroitUSA

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