Overview
Emphasizes metabolic pathophysiology and clinical applications of leptin in humans
Presents therapeutic trials of recombinant leptin replacement in humans for a variety of disorders
Considers the future direction of human leptin research and treatment possibilities
Includes supplementary material: sn.pub/extras
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Table of contents (21 chapters)
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Front Matter
Keywords
About this book
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone.
Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
Editors and Affiliations
About the editor
Sam Dagogo-Jack, MD, FRCP, A.C. Mullins Chair in Translational Research, Professor of Medicine and Director, Division of Endocrinology, Diabetes and Metabolism, Director, General Clinical Research Center, The University of Tennessee Health Science Center, Memphis, TN, USA
Bibliographic Information
Book Title: Leptin
Book Subtitle: Regulation and Clinical Applications
Editors: Sam Dagogo-Jack, MD
DOI: https://doi.org/10.1007/978-3-319-09915-6
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-09914-9Published: 03 December 2014
Softcover ISBN: 978-3-319-35413-2Published: 23 August 2016
eBook ISBN: 978-3-319-09915-6Published: 18 November 2014
Edition Number: 1
Number of Pages: XXIII, 287
Number of Illustrations: 21 b/w illustrations, 27 illustrations in colour
Topics: Endocrinology, Metabolic Diseases
Industry Sectors: Biotechnology, Health & Hospitals, Pharma