Biological Basis of Alcohol-Induced Cancer

1. Front Matter

   Pages i-xvi

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2. Introduction

   • Gary J. Murray

   Pages 1-6

3. Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data

   • Samir Zakhari, Jan B. Hoek

   Pages 7-39

4. Genetic–Epidemiological Evidence for the Role of Acetaldehyde in Cancers Related to Alcohol Drinking

   • C. J. Peter Eriksson

   Pages 41-58

5. Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1

   • Helmut K. Seitz, Sebastian Mueller

   Pages 59-70

6. Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis

   • Silvia Balbo, Philip J. Brooks

   Pages 71-88

7. The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis

   • Sebastian Mueller, Vanessa Rausch

   Pages 89-112

8. Alcoholic Cirrhosis and Hepatocellular Carcinoma

   • Felix Stickel

   Pages 113-130

9. TLR4-Dependent Tumor-Initiating Stem Cell-Like Cells (TICs) in Alcohol-Associated Hepatocellular Carcinogenesis

   • Keigo Machida, Douglas E. Feldman, Hidekazu Tsukamoto

   Pages 131-144Open Access

10. Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury

    • Arthur I. Cederbaum, Yongke Lu, Xiaodong Wang, Defeng Wu

    Pages 145-172

11. Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma

    • Colin T. Shearn, Dennis R. Petersen

    Pages 173-184

12. Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis

    • K. E. Mercer, L. Hennings, M. J. J. Ronis

    Pages 185-195

13. Alcohol and HCV: Implications for Liver Cancer

    • Gyongyi Szabo, Banishree Saha, Terence N. Bukong

    Pages 197-216

14. Application of Mass Spectrometry-Based Metabolomics in Identification of Early Noninvasive Biomarkers of Alcohol-Induced Liver Disease Using Mouse Model

    • Soumen K. Manna, Matthew D. Thompson, Frank J. Gonzalez

    Pages 217-238

15. Alcohol Metabolism by Oral Streptococci and Interaction with Human Papillomavirus Leads to Malignant Transformation of Oral Keratinocytes

    • Lin Tao, Sylvia I. Pavlova, Stephen R. Gasparovich, Ling Jin, Joel Schwartz

    Pages 239-264

16. Genetic Polymorphisms of Alcohol Dehydrogense-1B and Aldehyde Dehydrogenase-2, Alcohol Flushing, Mean Corpuscular Volume, and Aerodigestive Tract Neoplasia in Japanese Drinkers

    • Akira Yokoyama, Takeshi Mizukami, Tetsuji Yokoyama

    Pages 265-279

17. Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers

    • S. Singh, J. Arcaroli, D. C. Thompson, W. Messersmith, V. Vasiliou

    Pages 281-294

18. Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases

    • Benita McVicker, Dean J. Tuma, Kathryn E. Lazure, Peter Thomas, Carol A. Casey

    Pages 295-311

19. Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System

    • Hui Zhang, Zhaohui Zhu, Faya Zhang, Gary G. Meadows

    Pages 313-331

20. A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma

    • Sangeeta Shrotriya, Rajesh Agarwal, Robert A. Sclafani

    Pages 333-348

In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.

• acetaldehyde
• cirrhosis
• hepatocarcinogenesis
• liver cancer

• Department of Environmental Health Sciences, Yale School of Public Health, New Haven, USA

  Vasilis Vasiliou

• Distilled Spirits Council of the United States, Washington, USA

  Samir Zakhari

• Centre of Alcohol Research, University of Heidelberg, Germany and Salem Medical Centre, Heidelberg, Germany

  Helmut K. Seitz

• Department of Pathology, Anatomy, & Cell, Thomas Jefferson University, Philadelphia, USA

  Jan B. Hoek

Vasilils Vasiliou, Ph.D., is a Professor of Molecular Toxicology and Director of the Toxicology Graduate Program at the University of Colorado in Denver. He is a reviewer for several journals including Alcohol & Alcoholism, Cancer Letters, International Journal of Cancer. Dr. Vasiliou is also the Editor of the journal, Human Genomics, and also serves on the Editorial Board of several journals, including Journal of Pharmacology and Toxicology. He is a co-editor of Springer publication, Alcohol and Cancer.

Samir Zakhari, Ph.D., is the Senior Vice President of Science at the Distilled Spirits Council of the United States. Prior to Dr. Zakhari's current position, he was the Director of Basic Research at the National Institute on Alcohol Abuse and Alcoholism at the NIH. He is a co-editor of Springer publication, Alcohol and Cancer.

Helmut K. Seitz, MD, is a Distinguished Professor of Medicine, Gastroenterology, and Alcohol Research at the University Heidelberg. He is also the Director of the Salem Medical Center at the University of Heidelberg. 

Jan B. Hoek, Ph.D., is a Professor of Pathology, Anatomy, and Cell Biology, as well as Vice-Chair of Research at Thomas Jefferson University.

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